Setting description

Carboplatin more effective in the DRD+ biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 10 1 16 10
TP53- & AR- 30 31 123 133
TP53+ 5 2 24 27
DRD+ 0 1 267 280
TEfus+ 2 4 31 41
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.020 0.002 0.032 0.020
TP53- & AR- 0.060 0.062 0.246 0.266
TP53+ 0.010 0.004 0.048 0.054
DRD+ 0.000 0.002 0.534 0.560
TEfus+ 0.004 0.008 0.062 0.082
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 17 2 0 0
TP53- & AR- 220 185 8 2
TP53+ 63 63 1 1
DRD+ 78 92 0 0
TEfus+ 59 68 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.034 0.004 0.000 0.000
TP53- & AR- 0.440 0.370 0.016 0.004
TP53+ 0.126 0.126 0.002 0.002
DRD+ 0.156 0.184 0.000 0.000
TEfus+ 0.118 0.136 0.000 0.000
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 18 15 11 13
TP53+ 6 14 8 8
DRD+ 0 0 0 0
TEfus+ 0 0 0 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.036 0.030 0.022 0.026
TP53+ 0.012 0.028 0.016 0.016
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.004


Errors & power

The overall error was 0.372.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.094             0.076             0.136             0.130 

The overall power was 0.786.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.534             0.560 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 16 0 10 10 1
futility 0 0 17 0 2
max_n 0 0 0 0 0
n 184 (109, 254) 430 (397, 463) 176 (109, 252) 184 (117, 256) 181 (121, 262)
n_unique 170 (98, 239) 394 (364, 424) 162 (100, 235) 169 (107, 238) 169 (110, 247)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop 7 (6, 24) NA (NA, NA) 5 (4, 33) 10 (7, 29) 21 (7, 23)
post_p 1 (1, 1) NA (NA, NA) 0.41 (0.06, 0.84) 1 (1, 1) 0.46 (0.08, 0.85)
rate 0.072 (0.062, 0.084) 0.112 (0.105, 0.12) 0.114 (0.103, 0.129) 0.072 (0.062, 0.085) 0.112 (0.102, 0.126)
DRD+ graduation 267 0 0 280 1
futility 0 0 78 0 92
max_n 0 0 0 0 0
n 67 (27, 102) 118 (101, 135) 34 (19, 63) 65 (27, 103) 36 (24, 63)
n_unique 62 (25, 95) 107 (90, 123) 30 (17, 56) 60 (25, 96) 32 (22, 57)
time_trial 34 (12, 36) 36 (36, 36) 36 (31, 36) 32 (12, 36) 36 (28, 36)
time_stop 19 (11, 32) NA (NA, NA) 29 (22, 35) 18 (10, 32) 28 (21, 33)
post_p 1 (1, 1) NA (NA, NA) 0.36 (0.07, 0.77) 1 (1, 1) 0.36 (0.08, 0.8)
rate 0.036 (0.029, 0.045) 0.112 (0.098, 0.126) 0.115 (0.092, 0.152) 0.036 (0.028, 0.044) 0.114 (0.09, 0.145)
TEfus+ graduation 31 0 2 41 4
futility 0 0 59 0 68
max_n 0 0 0 2 0
n 70 (37, 105) 157 (139, 177) 63 (31, 91) 68 (40, 103) 72 (40, 101)
n_unique 64 (34, 98) 143 (126, 161) 57 (29, 84) 63 (37, 95) 67 (37, 92)
time_trial 36 (36, 36) 36 (36, 36) 36 (30, 36) 36 (36, 36) 36 (27, 36)
time_stop 14 (11, 20) NA (NA, NA) 23 (16, 32) 15 (11, 28) 23 (10, 32)
post_p 1 (0.94, 1) NA (NA, NA) 0.4 (0.07, 0.82) 1 (0.95, 1) 0.39 (0.07, 0.8)
rate 0.064 (0.051, 0.082) 0.112 (0.1, 0.125) 0.114 (0.095, 0.144) 0.065 (0.049, 0.079) 0.115 (0.097, 0.136)
TP53- & AR- graduation 123 0 30 133 31
futility 8 0 220 2 185
max_n 11 0 18 13 15
n 62 (27, 124) 180 (155, 205) 58 (26, 133) 65 (28, 125) 64 (26, 128)
n_unique 57 (25, 116) 166 (142, 188) 55 (25, 126) 59 (26, 117) 59 (24, 121)
time_trial 36 (14, 36) 36 (36, 36) 36 (10, 36) 36 (15, 36) 36 (16, 36)
time_stop 16 (10, 30) NA (NA, NA) 16 (7, 29) 18 (10, 31) 20 (12, 32)
post_p 0.99 (0.81, 1) NA (NA, NA) 0.41 (0.06, 0.83) 0.99 (0.82, 1) 0.42 (0.08, 0.87)
rate 0.072 (0.053, 0.093) 0.112 (0.101, 0.126) 0.117 (0.097, 0.146) 0.074 (0.052, 0.095) 0.114 (0.097, 0.149)
TP53+ graduation 24 0 5 27 2
futility 1 0 63 1 63
max_n 8 0 6 8 14
n 86 (47, 125) 190 (167, 211) 82 (37, 124) 83 (47, 124) 86 (46, 126)
n_unique 78 (42, 119) 172 (152, 193) 76 (34, 115) 78 (42, 114) 79 (40, 118)
time_trial 36 (36, 36) 36 (36, 36) 36 (29, 36) 36 (36, 36) 36 (26, 36)
time_stop 13 (9, 22) NA (NA, NA) 22 (9, 32) 16 (10, 32) 19 (10, 32)
post_p 0.99 (0.84, 1) NA (NA, NA) 0.4 (0.06, 0.84) 0.99 (0.84, 1) 0.4 (0.07, 0.87)
rate 0.075 (0.06, 0.093) 0.112 (0.101, 0.124) 0.113 (0.099, 0.141) 0.075 (0.059, 0.093) 0.114 (0.097, 0.138)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 144 0 273 142 217
futility 0 0 0 0 0
max_n 11 0 18 13 15
n 27 (9, 84) 114 (93, 135) 35 (16, 102) 29 (10, 89) 36 (12, 95)
n_unique 25 (8, 80) 106 (86, 126) 33 (16, 98) 26 (8, 84) 34 (10, 90)
post_p 0.46 (0.1, 0.89) NA (NA, NA) 0.44 (0.1, 0.87) 0.48 (0.08, 0.88) 0.46 (0.1, 0.87)
rate 0.117 (0.09, 0.186) 0.113 (0.099, 0.131) 0.118 (0.097, 0.159) 0.115 (0.092, 0.179) 0.116 (0.095, 0.175)
—+ graduation 167 0 294 167 248
futility 0 0 0 0 0
max_n 11 0 18 14 14
n 6 (2, 17) 22 (15, 30) 7 (2, 20) 6 (2, 18) 8 (3, 22)
n_unique 5 (1, 17) 20 (14, 27) 6 (2, 19) 5 (1, 16) 8 (3, 20)
post_p 0.47 (0.18, 0.82) NA (NA, NA) 0.43 (0.18, 0.81) 0.44 (0.18, 0.81) 0.44 (0.16, 0.85)
rate 0.12 (0.072, 0.279) 0.113 (0.081, 0.156) 0.128 (0.08, 0.289) 0.125 (0.071, 0.326) 0.125 (0.081, 0.272)
–+- graduation 39 0 90 37 66
futility 0 0 0 0 0
max_n 8 0 6 8 14
n 22 (6, 50) 63 (50, 77) 28 (8, 60) 23 (6, 53) 24 (7, 55)
n_unique 20 (5, 47) 57 (45, 72) 26 (8, 56) 21 (6, 49) 22 (6, 52)
post_p 0.44 (0.12, 0.87) NA (NA, NA) 0.45 (0.11, 0.87) 0.45 (0.1, 0.88) 0.41 (0.1, 0.86)
rate 0.118 (0.09, 0.21) 0.113 (0.093, 0.138) 0.119 (0.092, 0.181) 0.118 (0.089, 0.218) 0.121 (0.091, 0.206)
–++ graduation 63 0 127 66 121
futility 0 0 0 0 0
max_n 8 0 6 10 13
n 15 (4, 35) 42 (33, 53) 16 (4, 37) 13 (4, 33) 21 (7, 43)
n_unique 14 (3, 33) 39 (30, 49) 15 (4, 35) 12 (3, 31) 19 (6, 40)
post_p 0.5 (0.15, 0.85) NA (NA, NA) 0.43 (0.13, 0.84) 0.44 (0.13, 0.84) 0.45 (0.11, 0.87)
rate 0.115 (0.085, 0.226) 0.112 (0.089, 0.143) 0.121 (0.088, 0.261) 0.124 (0.085, 0.252) 0.119 (0.09, 0.22)
-+– graduation 332 0 313 333 264
futility 0 0 0 0 0
max_n 10 0 18 12 15
n 10 (3, 22) 21 (14, 29) 4 (0, 13) 10 (3, 22) 5 (2, 14)
n_unique 9 (3, 21) 19 (13, 26) 4 (0, 12) 9 (3, 21) 5 (2, 13)
post_p 0.96 (0.63, 1) NA (NA, NA) 0.36 (0.14, 0.66) 0.95 (0.7, 1) 0.34 (0.15, 0.66)
rate 0.037 (0.02, 0.07) 0.114 (0.084, 0.151) 0.126 (0.072, 0.406) 0.038 (0.021, 0.067) 0.125 (0.071, 0.34)
-+-+ graduation 337 0 328 338 288
futility 0 0 0 0 0
max_n 10 0 18 13 14
n 10 (3, 23) 21 (15, 28) 4 (0, 13) 10 (3, 23) 5 (1, 14)
n_unique 9 (3, 22) 19 (13, 26) 3 (0, 12) 9 (3, 21) 4 (1, 13)
post_p 0.95 (0.69, 1) NA (NA, NA) 0.35 (0.17, 0.65) 0.96 (0.72, 1) 0.32 (0.13, 0.67)
rate 0.036 (0.018, 0.066) 0.112 (0.083, 0.151) 0.133 (0.073, 0.405) 0.036 (0.019, 0.066) 0.128 (0.072, 0.365)
-++- graduation 282 0 152 293 149
futility 0 0 0 0 0
max_n 7 0 6 7 13
n 6 (2, 14) 12 (8, 18) 3 (1, 9) 6 (2, 13) 4 (1, 9)
n_unique 6 (1, 13) 11 (7, 17) 3 (0, 8) 5 (1, 12) 3 (1, 8)
post_p 0.87 (0.5, 0.99) NA (NA, NA) 0.34 (0.16, 0.65) 0.86 (0.5, 0.99) 0.36 (0.18, 0.63)
rate 0.038 (0.016, 0.095) 0.114 (0.074, 0.175) 0.139 (0.068, 0.51) 0.036 (0.015, 0.1) 0.133 (0.065, 0.474)
-+++ graduation 287 0 183 299 190
futility 0 0 0 0 0
max_n 7 0 6 9 13
n 6 (1, 14) 12 (8, 18) 4 (1, 10) 6 (2, 14) 4 (1, 9)
n_unique 6 (1, 13) 11 (7, 16) 3 (1, 9) 5 (1, 13) 3 (1, 8)
post_p 0.88 (0.49, 0.99) NA (NA, NA) 0.36 (0.18, 0.65) 0.86 (0.49, 0.99) 0.36 (0.17, 0.65)
rate 0.038 (0.013, 0.099) 0.113 (0.076, 0.171) 0.131 (0.068, 0.426) 0.038 (0.013, 0.094) 0.133 (0.064, 0.351)
+— graduation 16 0 27 10 3
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (2, 18) 20 (14, 27) 8 (2, 18) 8 (3, 17) 11 (4, 21)
n_unique 7 (2, 16) 18 (13, 24) 7 (2, 17) 7 (2, 15) 10 (4, 20)
post_p 0.47 (0.19, 0.85) NA (NA, NA) 0.42 (0.18, 0.84) 0.46 (0.18, 0.85) 0.49 (0.16, 0.81)
rate 0.124 (0.073, 0.294) 0.117 (0.085, 0.16) 0.129 (0.078, 0.316) 0.124 (0.072, 0.349) 0.121 (0.082, 0.258)
+–+ graduation 46 0 84 46 73
futility 0 0 0 0 0
max_n 0 0 0 2 0
n 6 (2, 13) 16 (11, 22) 7 (2, 16) 6 (2, 14) 8 (3, 18)
n_unique 5 (1, 12) 15 (10, 21) 6 (2, 15) 5 (2, 13) 8 (3, 16)
post_p 0.45 (0.2, 0.84) NA (NA, NA) 0.43 (0.18, 0.83) 0.48 (0.2, 0.81) 0.44 (0.17, 0.86)
rate 0.131 (0.071, 0.428) 0.116 (0.079, 0.166) 0.132 (0.075, 0.406) 0.125 (0.068, 0.37) 0.127 (0.073, 0.268)
+-+- graduation 39 0 90 37 66
futility 0 0 0 0 0
max_n 8 0 6 8 14
n 6 (2, 15) 16 (11, 22) 6 (1, 15) 6 (2, 14) 8 (2, 16)
n_unique 5 (1, 13) 15 (10, 20) 6 (1, 14) 5 (2, 13) 7 (2, 15)
post_p 0.46 (0.2, 0.82) NA (NA, NA) 0.44 (0.2, 0.84) 0.45 (0.19, 0.82) 0.46 (0.18, 0.83)
rate 0.125 (0.071, 0.388) 0.114 (0.08, 0.167) 0.128 (0.072, 0.361) 0.125 (0.073, 0.371) 0.123 (0.074, 0.328)
+-++ graduation 63 0 127 66 121
futility 0 0 0 0 0
max_n 8 0 6 10 13
n 6 (2, 14) 17 (11, 22) 6 (2, 15) 6 (2, 14) 8 (3, 17)
n_unique 5 (1, 13) 15 (10, 20) 5 (2, 14) 6 (2, 13) 8 (2, 16)
post_p 0.45 (0.2, 0.81) NA (NA, NA) 0.42 (0.19, 0.83) 0.49 (0.22, 0.84) 0.47 (0.19, 0.84)
rate 0.13 (0.075, 0.321) 0.113 (0.079, 0.167) 0.134 (0.072, 0.354) 0.118 (0.071, 0.337) 0.122 (0.079, 0.311)
++– graduation 278 0 102 285 95
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 14) 12 (8, 17) 3 (1, 9) 6 (2, 14) 3 (1, 9)
n_unique 6 (2, 13) 11 (7, 16) 3 (1, 8) 5 (2, 13) 3 (1, 8)
post_p 0.88 (0.51, 0.99) NA (NA, NA) 0.36 (0.17, 0.66) 0.87 (0.48, 0.99) 0.36 (0.19, 0.68)
rate 0.037 (0.014, 0.095) 0.115 (0.075, 0.178) 0.132 (0.062, 0.439) 0.037 (0.014, 0.1) 0.13 (0.063, 0.445)
++-+ graduation 284 0 148 292 149
futility 0 0 0 0 0
max_n 0 0 0 2 0
n 6 (2, 14) 12 (8, 17) 4 (1, 9) 6 (2, 14) 4 (1, 8)
n_unique 5 (2, 13) 11 (7, 16) 3 (1, 8) 6 (1, 13) 3 (1, 8)
post_p 0.86 (0.51, 0.98) NA (NA, NA) 0.35 (0.16, 0.67) 0.89 (0.57, 0.98) 0.35 (0.18, 0.64)
rate 0.037 (0.015, 0.093) 0.112 (0.073, 0.171) 0.131 (0.061, 0.39) 0.036 (0.014, 0.08) 0.136 (0.063, 0.397)
+++- graduation 282 0 152 293 149
futility 0 0 0 0 0
max_n 7 0 6 7 13
n 6 (2, 14) 12 (8, 17) 3 (1, 9) 6 (2, 14) 4 (1, 9)
n_unique 6 (1, 13) 11 (7, 16) 3 (1, 9) 5 (1, 13) 3 (1, 8)
post_p 0.85 (0.54, 0.98) NA (NA, NA) 0.36 (0.16, 0.65) 0.87 (0.52, 0.99) 0.36 (0.18, 0.65)
rate 0.038 (0.017, 0.085) 0.112 (0.074, 0.179) 0.129 (0.059, 0.333) 0.035 (0.014, 0.087) 0.129 (0.062, 0.392)
++++ graduation 287 0 183 299 190
futility 0 0 0 0 0
max_n 7 0 6 9 13
n 5 (2, 13) 12 (8, 18) 4 (1, 9) 6 (2, 14) 3 (1, 9)
n_unique 5 (1, 13) 11 (7, 16) 3 (1, 8) 5 (1, 13) 3 (1, 9)
post_p 0.86 (0.49, 0.98) NA (NA, NA) 0.38 (0.18, 0.69) 0.88 (0.47, 0.98) 0.36 (0.17, 0.64)
rate 0.038 (0.015, 0.097) 0.11 (0.071, 0.177) 0.122 (0.057, 0.386) 0.037 (0.015, 0.092) 0.132 (0.061, 0.431)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 10 1 16 10
time_stop 5 (4, 6) 4 (4, 4) 7 (6, 24) 10 (7, 29)
n_trt 31 (29, 41) 25 (25, 25) 36 (28, 130) 50 (36, 118)
n_control 56 (51, 70) 43 (43, 43) 76 (60, 300) 108 (78, 348)
post_p 0.89 (0.86, 0.93) 0.88 (0.88, 0.88) 1 (0.97, 1) 1 (0.98, 1)
order 1 (1, 1) 1 (1, 1) 1 (1, 3.5) 1 (1, 6)
TP53- & AR- count 30 31 123 133
time_stop 9 (6, 15) 15 (11, 23) 15 (10, 30) 18 (10, 31)
n_trt 30 (26, 46) 36 (27, 56) 33 (26, 77) 41 (25, 93)
n_control 43 (27, 67) 63 (51, 111) 69 (41, 149) 79 (46, 148)
post_p 0.9 (0.86, 0.96) 0.92 (0.88, 0.96) 0.98 (0.91, 1) 0.99 (0.92, 1)
order 1 (1, 1.1) 1 (1, 3) 2 (1, 3) 2 (1, 3)
TP53+ count 5 2 24 27
time_stop 9 (8, 10) 8 (7, 10) 13 (9, 22) 16 (10, 32)
n_trt 29 (26, 30) 26 (25, 28) 33 (26, 60) 39 (27, 103)
n_control 38 (33, 44) 46 (38, 54) 64 (41, 109) 73 (41, 176)
post_p 0.95 (0.92, 0.97) 0.9 (0.9, 0.9) 1 (0.94, 1) 1 (0.94, 1)
order 1 (1, 1) 1.5 (1.1, 1.9) 2 (1, 3.7) 2 (1, 3.4)
DRD+ count 1 267 280
time_stop 21 (21, 21) 19 (11, 32) 18 (10, 32)
n_trt 25 (25, 25) 41 (26, 83) 42 (26, 86)
n_control 69 (69, 69) 57 (28, 100) 50 (27, 108)
post_p 0.98 (0.98, 0.98) 1 (0.98, 1) 1 (0.98, 1)
order 1 (1, 1) 2 (1, 4) 2 (1, 3)
TEfus+ count 2 4 31 41
time_stop 12 (11, 13) 10 (9, 11) 14 (11, 20) 15 (11, 28)
n_trt 30 (28, 32) 28 (25, 31) 28 (25, 42) 29 (25, 67)
n_control 50 (45, 54) 32 (31, 42) 51 (42, 79) 57 (40, 103)
post_p 0.96 (0.94, 0.97) 0.94 (0.88, 0.95) 1 (0.95, 1) 1 (0.97, 1)
order 1.5 (1.1, 1.9) 1 (1, 1) 2 (1, 3) 2 (1, 4)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 17 2
time_stop 5 (4, 35) 22 (21, 24)
n_trt 31 (25, 135) 98 (80, 116)
n_control 50 (37, 411) 258 (244, 271)
post_p 0.08 (0, 0.18) 0.01 (0.01, 0.02)
order 1 (1, 4.4) 4.5 (4.1, 4.9)
TP53- & AR- count 220 185 8 2
time_stop 16 (8, 30) 21 (13, 32) 17 (15, 24) 17 (15, 19)
n_trt 38 (26, 74) 35 (25, 80) 34 (28, 66) 44 (29, 58)
n_control 74 (32, 148) 101 (55, 162) 71 (60, 140) 89 (75, 103)
post_p 0.15 (0.05, 0.27) 0.16 (0.05, 0.27) 0.17 (0.12, 0.27) 0.16 (0.13, 0.19)
order 1 (1, 2) 2 (1, 3) 2 (1, 3.3) 2 (1.2, 2.8)
TP53+ count 63 63 1 1
time_stop 23 (11, 33) 19 (10, 32) 11 (11, 11) 10 (10, 10)
n_trt 41 (26, 77) 38 (26, 68) 26 (26, 26) 25 (25, 25)
n_control 113 (46, 178) 88 (38, 174) 40 (40, 40) 39 (39, 39)
post_p 0.08 (0.01, 0.24) 0.08 (0.01, 0.22) 0.13 (0.13, 0.13) 0.09 (0.09, 0.09)
order 2 (1, 4) 1 (1, 3) 1 (1, 1) 1 (1, 1)
DRD+ count 78 92
time_stop 29 (22, 35) 28 (21, 33)
n_trt 31 (25, 47) 29 (25, 50)
n_control 91 (66, 112) 90 (59, 117)
post_p 0.08 (0.02, 0.24) 0.1 (0.02, 0.22)
order 2 (1, 4) 2 (1, 4)
TEfus+ count 59 68
time_stop 23 (16, 32) 23 (13, 32)
n_trt 35 (26, 55) 40 (27, 64)
n_control 94 (60, 142) 91 (46, 140)
post_p 0.07 (0.01, 0.19) 0.06 (0.02, 0.21)
order 2 (1, 4) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
time 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24) 7 (6, 24)
n 8 (2, 26) 2 (0, 6) 6 (3, 20) 3 (0, 14) 4 (0, 8) 3 (1, 6) 2 (0, 4) 1 (0, 4) 0 (0, 7) 2 (0, 6) 1 (0, 5) 1 (0, 7) 2 (0, 6) 3 (1, 6) 2 (1, 6) 2 (0, 4)
post_p 0.71 (0.6, 0.8) 0.64 (0.55, 0.71) 0.63 (0.53, 0.7) 0.59 (0.56, 0.7) 0.58 (0.5, 0.76) 0.64 (0.54, 0.8) 0.58 (0.53, 0.8) 0.58 (0.52, 0.71) 0.54 (0.51, 0.7) 0.59 (0.54, 0.74) 0.56 (0.51, 0.65) 0.61 (0.51, 0.74) 0.73 (0.55, 0.93) 0.61 (0.53, 0.82) 0.67 (0.53, 0.87) 0.63 (0.51, 0.71)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.036 (0, 0.094) 0 (0, 0.093) 0.074 (0, 0.099) 0.017 (0, 0.121) 0 (0, 0.049) 0 (0, 0.074) 0 (0, 0.04) 0 (0, 0.039) 0 (0, 0.119) 0 (0, 0.095) 0 (0, 0.091) 0 (0, 0.097) 0 (0, 0.028) 0 (0, 0.044) 0 (0, 0.042) 0 (0, 0.075)
Hormone_therapies count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
time 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6) 5 (4, 6)
n 15 (13, 16) 2 (1, 5) 8 (6, 10) 4 (1, 7) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 3) 2 (0, 3) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
post_p 0.74 (0.64, 0.93) 0.6 (0.52, 0.65) 0.68 (0.6, 0.78) 0.7 (0.54, 0.75) NA (NA, NA) 0.53 (0.51, 0.59) 0.51 (0.51, 0.51) 0.54 (0.53, 0.55) 0.65 (0.57, 0.7) 0.64 (0.52, 0.74) 0.56 (0.55, 0.6) 0.57 (0.53, 0.6) NA (NA, NA) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) 0.51 (0.5, 0.53)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.045 (0.023, 0.073) 0.043 (0, 0.204) 0.039 (0, 0.08) 0 (0, 0.113) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.125) 0 (0, 0) 0 (0, 0.099) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
time 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29) 10 (7, 29)
n 11 (4, 31) 2 (0, 4) 8 (5, 24) 4 (2, 13) 3 (0, 8) 6 (5, 7) 2 (1, 6) 3 (1, 4) 2 (0, 13) 0 (0, 4) 1 (1, 6) 2 (0, 3) 2 (1, 4) 3 (1, 5) 3 (2, 4) 2 (0, 4)
post_p 0.65 (0.5, 0.84) 0.7 (0.54, 0.81) 0.6 (0.55, 0.88) 0.68 (0.61, 0.86) 0.7 (0.56, 0.95) 0.73 (0.61, 0.96) 0.67 (0.6, 0.8) 0.64 (0.53, 0.77) 0.58 (0.51, 0.75) 0.57 (0.55, 0.6) 0.56 (0.5, 0.69) 0.56 (0.52, 0.8) 0.76 (0.56, 0.96) 0.61 (0.52, 0.89) 0.69 (0.59, 0.81) 0.7 (0.51, 0.89)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.09 (0.028, 0.116) 0.059 (0, 0.08) 0.097 (0, 0.127) 0.027 (0, 0.069) 0.025 (0, 0.033) 0.032 (0, 0.066) 0 (0, 0.053) 0.039 (0, 0.089) 0.046 (0, 0.099) 0.072 (0.026, 0.091) 0 (0, 0.134) 0 (0, 0.108) 0 (0, 0.022) 0.004 (0, 0.11) 0.025 (0, 0.069) 0 (0, 0.025)
Taxel_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 5 (5, 5) 0 (0, 0) 7 (7, 7) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 2 (2, 2) 5 (5, 5) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.76 (0.76, 0.76) NA (NA, NA) 0.53 (0.53, 0.53) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.76 (0.76, 0.76) NA (NA, NA) 0.51 (0.51, 0.51) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.12 (0.12, 0.12) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.069 (0.069, 0.069) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
DRD+ Carboplatin count 267 267 267 267 267 267 267 267
time 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32) 19 (11, 32)
n 7 (3, 17) 8 (3, 16) 5 (2, 11) 5 (1, 11) 4 (1, 10) 4 (2, 11) 4 (1, 11) 4 (1, 11)
post_p 0.81 (0.6, 0.97) 0.81 (0.62, 0.97) 0.74 (0.56, 0.95) 0.74 (0.53, 0.94) 0.74 (0.54, 0.93) 0.75 (0.54, 0.94) 0.74 (0.55, 0.93) 0.74 (0.54, 0.95)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.035 (0, 0.064) 0.033 (0, 0.064) 0.028 (0, 0.068) 0.03 (0, 0.071) 0.029 (0, 0.074) 0.029 (0, 0.077) 0.031 (0, 0.068) 0.028 (0, 0.068)
Niraparib count 280 280 280 280 280 280 280 280
time 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32) 18 (10, 32)
n 7 (3, 16) 8 (3, 17) 4 (1, 11) 4 (1, 10) 4 (1, 11) 4 (1, 11) 4 (2, 11) 4 (1, 11)
post_p 0.8 (0.59, 0.98) 0.82 (0.62, 0.98) 0.74 (0.54, 0.93) 0.72 (0.54, 0.93) 0.74 (0.54, 0.93) 0.76 (0.56, 0.94) 0.72 (0.53, 0.92) 0.75 (0.54, 0.95)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.07) 0.029 (0, 0.06) 0.028 (0, 0.071) 0.03 (0, 0.072) 0.028 (0, 0.07) 0.027 (0, 0.068) 0.029 (0, 0.072) 0.026 (0, 0.068)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21) 21 (21, 21)
n 4 (4, 4) 4 (4, 4) 4 (4, 4) 0 (0, 0) 1 (1, 1) 5 (5, 5) 3 (3, 3) 4 (4, 4)
post_p 0.67 (0.67, 0.67) 0.54 (0.54, 0.54) 0.5 (0.5, 0.5) NA (NA, NA) 0.5 (0.5, 0.5) 0.84 (0.84, 0.84) 0.87 (0.87, 0.87) 0.5 (0.5, 0.5)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.06 (0.06, 0.06) 0.114 (0.114, 0.114) 0.081 (0.081, 0.081) NA (NA, NA) 0 (0, 0) 0.039 (0.039, 0.039) 0 (0, 0) 0.07 (0.07, 0.07)
TEfus+ Carboplatin count 31 31 31 31 31 31 31 31
time 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20) 14 (11, 20)
n 3 (1, 5) 6 (3, 14) 5 (4, 8) 3 (2, 6) 2 (1, 5) 3 (1, 7) 3 (1, 5) 4 (1, 5)
post_p 0.61 (0.51, 0.73) 0.73 (0.53, 0.8) 0.77 (0.61, 0.92) 0.73 (0.55, 0.91) 0.61 (0.53, 0.85) 0.68 (0.54, 0.8) 0.68 (0.58, 0.82) 0.7 (0.53, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.071 (0, 0.127) 0.075 (0.04, 0.1) 0.03 (0, 0.061) 0 (0, 0.064) 0.036 (0, 0.115) 0.045 (0, 0.117) 0.031 (0, 0.087) 0.008 (0, 0.076)
Hormone_therapies count 2 2 2 2 2 2 2 2
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 6 (3, 8) 14 (10, 18) 1 (0, 2) 2 (0, 3) 2 (1, 4) 3 (2, 4) 2 (1, 2) 2 (0, 3)
post_p 0.75 (0.69, 0.81) 0.87 (0.83, 0.91) 0.69 (0.69, 0.69) 0.5 (0.5, 0.5) 0.66 (0.61, 0.71) 0.52 (0.51, 0.52) 0.54 (0.54, 0.54) 0.59 (0.59, 0.59)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.017 (0.003, 0.031) 0.055 (0.05, 0.061) 0 (0, 0) 0 (0, 0) 0.031 (0.006, 0.056) 0.025 (0.005, 0.045) 0 (0, 0) 0 (0, 0)
Niraparib count 41 41 41 41 41 41 41 41
time 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28) 15 (11, 28)
n 3 (1, 7) 7 (3, 18) 7 (4, 12) 3 (2, 7) 3 (1, 7) 3 (0, 7) 4 (1, 8) 3 (1, 8)
post_p 0.64 (0.53, 0.84) 0.75 (0.6, 0.86) 0.83 (0.72, 0.94) 0.72 (0.54, 0.89) 0.6 (0.52, 0.84) 0.67 (0.55, 0.81) 0.71 (0.52, 0.88) 0.7 (0.55, 0.92)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.059 (0, 0.098) 0.066 (0, 0.097) 0.019 (0, 0.054) 0.023 (0, 0.069) 0.033 (0, 0.12) 0.065 (0, 0.113) 0.029 (0, 0.086) 0.014 (0, 0.07)
Taxel_therapies count 4 4 4 4 4 4 4 4
time 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11)
n 4 (4, 5) 8 (6, 13) 1 (0, 3) 1 (0, 2) 4 (3, 6) 3 (3, 4) 2 (1, 4) 2 (1, 2)
post_p 0.68 (0.65, 0.74) 0.81 (0.66, 0.95) 0.58 (0.52, 0.72) 0.52 (0.52, 0.53) 0.7 (0.56, 0.94) 0.7 (0.64, 0.75) 0.54 (0.51, 0.64) 0.53 (0.52, 0.61)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.054 (0.048, 0.096) 0.085 (0.063, 0.088) 0 (0, 0) 0 (0, 0) 0.043 (0, 0.086) 0.1 (0.067, 0.145) 0 (0, 0) 0 (0, 0)
TP53- & AR- Carboplatin count 123 123 123 123
time 15 (10, 30) 15 (10, 30) 15 (10, 30) 15 (10, 30)
n 19 (12, 48) 3 (1, 8) 6 (3, 15) 6 (3, 15)
post_p 0.78 (0.71, 0.91) 0.61 (0.51, 0.79) 0.79 (0.54, 0.98) 0.78 (0.56, 0.98)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.076 (0.04, 0.103) 0.068 (0, 0.114) 0.031 (0, 0.071) 0.03 (0, 0.066)
Hormone_therapies count 30 30 30 30
time 9 (6, 15) 9 (6, 15) 9 (6, 15) 9 (6, 15)
n 24 (20, 34) 3 (2, 8) 1 (0, 5) 1 (0, 3)
post_p 0.89 (0.76, 0.96) 0.63 (0.52, 0.85) 0.62 (0.5, 0.74) 0.55 (0.51, 0.68)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.067 (0.035, 0.102) 0.056 (0, 0.121) 0 (0, 0.07) 0 (0, 0.071)
Niraparib count 133 133 133 133
time 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31)
n 20 (12, 61) 4 (1, 12) 6 (3, 14) 8 (3, 14)
post_p 0.76 (0.71, 0.93) 0.64 (0.51, 0.81) 0.87 (0.62, 0.98) 0.82 (0.67, 0.97)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.079 (0.047, 0.104) 0.074 (0, 0.126) 0.032 (0, 0.06) 0.031 (0, 0.06)
Taxel_therapies count 31 31 31 31
time 15 (11, 23) 15 (11, 23) 15 (11, 23) 15 (11, 23)
n 27 (16, 36) 5 (2, 13) 3 (0, 5) 2 (0, 5)
post_p 0.79 (0.73, 0.91) 0.72 (0.54, 0.91) 0.58 (0.51, 0.73) 0.58 (0.52, 0.79)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.056, 0.096) 0.06 (0, 0.112) 0.048 (0, 0.097) 0.016 (0, 0.077)
TP53+ Carboplatin count 24 24 24 24 24 24 24 24
time 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22) 13 (9, 22)
n 10 (4, 17) 5 (1, 15) 4 (1, 7) 2 (1, 6) 3 (1, 5) 3 (0, 7) 3 (1, 8) 3 (1, 6)
post_p 0.79 (0.55, 0.89) 0.72 (0.54, 0.8) 0.66 (0.56, 0.86) 0.64 (0.54, 0.8) 0.63 (0.53, 0.78) 0.68 (0.56, 0.86) 0.65 (0.54, 0.87) 0.69 (0.56, 0.85)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.071 (0.008, 0.101) 0.076 (0, 0.11) 0 (0, 0.041) 0.037 (0, 0.06) 0.058 (0, 0.11) 0.057 (0, 0.11) 0 (0, 0.076) 0 (0, 0.079)
Hormone_therapies count 5 5 5 5 5 5 5 5
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 16 (14, 19) 4 (3, 7) 2 (1, 3) 0 (0, 2) 2 (0, 3) 1 (0, 3) 1 (0, 2) 0 (0, 1)
post_p 0.86 (0.8, 0.94) 0.73 (0.66, 0.78) 0.58 (0.55, 0.61) 0.6 (0.55, 0.64) 0.6 (0.57, 0.76) 0.59 (0.54, 0.66) 0.54 (0.51, 0.57) 0.5 (0.5, 0.5)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.041 (0.022, 0.071) 0.048 (0, 0.063) 0 (0, 0) 0 (0, 0) 0 (0, 0.081) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 27 27 27 27 27 27 27 27
time 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32) 16 (10, 32)
n 16 (5, 34) 7 (3, 22) 4 (1, 7) 3 (0, 7) 3 (0, 11) 2 (1, 10) 4 (1, 11) 3 (2, 7)
post_p 0.75 (0.57, 0.91) 0.71 (0.57, 0.9) 0.78 (0.61, 0.91) 0.69 (0.51, 0.87) 0.7 (0.52, 0.89) 0.63 (0.54, 0.88) 0.74 (0.52, 0.95) 0.72 (0.54, 0.89)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.086 (0.055, 0.107) 0.08 (0.028, 0.112) 0.03 (0, 0.085) 0.032 (0, 0.078) 0.056 (0, 0.104) 0.067 (0, 0.111) 0.027 (0, 0.07) 0.014 (0, 0.065)
Taxel_therapies count 2 2 2 2 2 2 2 2
time 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10) 8 (7, 10)
n 6 (3, 10) 8 (5, 11) 1 (1, 1) 2 (0, 3) 3 (3, 3) 4 (3, 6) 0 (0, 1) 2 (1, 2)
post_p 0.63 (0.56, 0.71) 0.74 (0.73, 0.74) 0.51 (0.5, 0.52) 0.55 (0.55, 0.55) 0.6 (0.56, 0.63) 0.76 (0.63, 0.89) 0.51 (0.51, 0.51) 0.56 (0.55, 0.58)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.098, 0.155) 0.054 (0.011, 0.097) 0 (0, 0) 0 (0, 0) 0.078 (0.061, 0.096) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17
time 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35) 5 (4, 35)
n 15 (11, 32) 2 (1, 6) 7 (4, 29) 2 (1, 9) 0 (0, 4) 0 (0, 7) 0 (0, 3) 0 (0, 2) 2 (0, 12) 2 (0, 5) 1 (0, 6) 2 (0, 6) 0 (0, 3) 0 (0, 4) 0 (0, 3) 0 (0, 2)
post_p 0.27 (0.05, 0.45) 0.32 (0.23, 0.41) 0.33 (0.16, 0.39) 0.34 (0.26, 0.43) 0.33 (0.17, 0.5) 0.39 (0.29, 0.47) 0.18 (0.16, 0.37) 0.36 (0.31, 0.46) 0.36 (0.19, 0.48) 0.36 (0.25, 0.45) 0.33 (0.22, 0.48) 0.41 (0.37, 0.49) 0.39 (0.26, 0.47) 0.33 (0.27, 0.47) 0.4 (0.13, 0.46) 0.36 (0.33, 0.41)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.134 (0.078, 0.274) 0.18 (0.041, 0.346) 0.177 (0.117, 0.27) 0.228 (0.054, 0.6) 0.152 (0, 0.594) 0.108 (0.097, 0.839) 0.192 (0.06, 0.826) 0.974 (0.082, 5.57) 0.081 (0, 0.225) 0.158 (0, 0.272) 0.155 (0, 0.766) 0.19 (0.041, 0.258) 0.151 (0.076, 0.539) 0.108 (0, 0.205) 0.142 (0, 0.294) 0.33 (0.124, 27.05)
Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24) 22 (21, 24)
n 27 (21, 33) 6 (4, 7) 8 (6, 9) 9 (4, 14) 3 (2, 4) 10 (5, 14) 3 (2, 4) 3 (2, 4) 6 (5, 6) 4 (4, 4) 2 (2, 3) 6 (5, 8) 4 (2, 5) 2 (1, 4) 5 (3, 7) 2 (1, 2)
post_p 0.38 (0.35, 0.41) 0.31 (0.29, 0.33) 0.22 (0.22, 0.22) 0.3 (0.19, 0.41) 0.28 (0.27, 0.29) 0.24 (0.2, 0.29) 0.23 (0.2, 0.26) 0.38 (0.37, 0.4) 0.3 (0.15, 0.45) 0.45 (0.44, 0.45) 0.25 (0.17, 0.32) 0.39 (0.38, 0.41) 0.37 (0.3, 0.44) 0.18 (0.08, 0.28) 0.3 (0.22, 0.38) 0.19 (0.06, 0.33)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.13 (0.123, 0.138) 0.183 (0.156, 0.209) 0.226 (0.199, 0.253) 0.276 (0.167, 0.386) 0.263 (0.176, 0.349) 0.176 (0.143, 0.209) 0.223 (0.202, 0.245) 0.173 (0.123, 0.223) 0.223 (0.142, 0.305) 0.215 (0.207, 0.223) 0.285 (0.26, 0.309) 0.144 (0.127, 0.162) 0.069 (0.065, 0.074) 0.224 (0.174, 0.275) 0.802 (0.26, 1.345) 0.239 (0.236, 0.242)
DRD+ Hormone_therapies count 78 78 78 78 78 78 78 78
time 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35) 29 (22, 35)
n 4 (2, 10) 5 (1, 12) 3 (1, 8) 3 (1, 7) 3 (1, 7) 4 (1, 6) 4 (1, 7) 3 (1, 7)
post_p 0.33 (0.12, 0.48) 0.31 (0.17, 0.45) 0.3 (0.16, 0.45) 0.32 (0.18, 0.45) 0.33 (0.18, 0.46) 0.31 (0.16, 0.47) 0.32 (0.15, 0.46) 0.35 (0.19, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.158 (0.091, 0.488) 0.125 (0.087, 0.35) 0.172 (0.083, 0.679) 0.152 (0.089, 0.578) 0.147 (0.092, 0.599) 0.173 (0.101, 0.493) 0.15 (0.093, 0.422) 0.148 (0.093, 0.524)
Taxel_therapies count 92 92 92 92 92 92 92 92
time 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33) 28 (21, 33)
n 5 (2, 11) 5 (2, 11) 3 (1, 7) 3 (1, 7) 3 (1, 6) 3 (1, 8) 3 (1, 7) 3 (1, 8)
post_p 0.31 (0.17, 0.47) 0.32 (0.13, 0.48) 0.34 (0.2, 0.46) 0.33 (0.15, 0.47) 0.33 (0.17, 0.46) 0.34 (0.16, 0.45) 0.35 (0.19, 0.48) 0.3 (0.14, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.133 (0.089, 0.302) 0.143 (0.083, 0.37) 0.16 (0.085, 0.473) 0.144 (0.094, 0.51) 0.167 (0.09, 1.203) 0.139 (0.085, 0.447) 0.157 (0.083, 0.424) 0.153 (0.096, 0.646)
TEfus+ Hormone_therapies count 59 59 59 59 59 59 59 59
time 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32) 23 (16, 32)
n 4 (2, 9) 9 (4, 22) 4 (0, 9) 3 (0, 6) 3 (1, 9) 3 (1, 7) 2 (1, 5) 3 (1, 6)
post_p 0.31 (0.12, 0.46) 0.34 (0.14, 0.47) 0.32 (0.16, 0.47) 0.37 (0.22, 0.46) 0.31 (0.18, 0.46) 0.34 (0.2, 0.46) 0.33 (0.21, 0.47) 0.35 (0.18, 0.48)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.186 (0.112, 0.525) 0.156 (0.111, 0.265) 0.13 (0.087, 0.658) 0.139 (0.076, 0.586) 0.188 (0.108, 0.682) 0.179 (0.107, 0.386) 0.162 (0.086, 0.545) 0.148 (0.077, 0.501)
Taxel_therapies count 68 68 68 68 68 68 68 68
time 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32)
n 5 (2, 11) 10 (6, 26) 3 (1, 7) 2 (1, 5) 5 (2, 10) 5 (2, 8) 2 (1, 7) 3 (0, 7)
post_p 0.33 (0.13, 0.47) 0.29 (0.1, 0.47) 0.31 (0.16, 0.46) 0.32 (0.18, 0.48) 0.34 (0.19, 0.49) 0.35 (0.17, 0.48) 0.35 (0.16, 0.48) 0.39 (0.18, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.165 (0.112, 0.418) 0.142 (0.102, 0.298) 0.165 (0.082, 0.497) 0.163 (0.076, 0.363) 0.16 (0.095, 0.326) 0.167 (0.099, 0.443) 0.155 (0.079, 0.453) 0.146 (0.063, 0.393)
TP53- & AR- Carboplatin count 8 8 8 8
time 17 (15, 24) 17 (15, 24) 17 (15, 24) 17 (15, 24)
n 24 (16, 42) 3 (1, 12) 4 (1, 7) 4 (2, 12)
post_p 0.28 (0.12, 0.44) 0.39 (0.17, 0.44) 0.29 (0.12, 0.43) 0.41 (0.32, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.14 (0.117, 0.189) 0.164 (0.107, 0.225) 0.212 (0.085, 0.539) 0.118 (0.055, 0.288)
Hormone_therapies count 220 220 220 220
time 16 (8, 30) 16 (8, 30) 16 (8, 30) 16 (8, 30)
n 24 (16, 56) 5 (2, 11) 3 (0, 8) 3 (0, 7)
post_p 0.32 (0.11, 0.47) 0.38 (0.18, 0.49) 0.35 (0.17, 0.48) 0.36 (0.17, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.107, 0.173) 0.153 (0.089, 0.349) 0.139 (0.071, 0.538) 0.141 (0.069, 0.58)
Niraparib count 2 2 2 2
time 17 (15, 19) 17 (15, 19) 17 (15, 19) 17 (15, 19)
n 32 (18, 47) 2 (2, 3) 4 (3, 4) 5 (4, 6)
post_p 0.34 (0.27, 0.41) 0.21 (0.16, 0.26) 0.3 (0.2, 0.39) 0.4 (0.39, 0.4)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.138 (0.121, 0.155) 0.573 (0.374, 0.773) 0.231 (0.144, 0.318) 0.118 (0.084, 0.153)
Taxel_therapies count 185 185 185 185
time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
n 21 (10, 60) 6 (3, 13) 4 (1, 10) 4 (1, 9)
post_p 0.34 (0.1, 0.47) 0.34 (0.15, 0.47) 0.32 (0.16, 0.47) 0.32 (0.15, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.106, 0.193) 0.155 (0.107, 0.345) 0.151 (0.083, 0.55) 0.142 (0.085, 0.428)
TP53+ Carboplatin count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 12 (12, 12) 5 (5, 5) 0 (0, 0) 2 (2, 2) 1 (1, 1) 1 (1, 1) 3 (3, 3) 2 (2, 2)
post_p 0.36 (0.36, 0.36) 0.47 (0.47, 0.47) NA (NA, NA) 0.38 (0.38, 0.38) 0.34 (0.34, 0.34) 0.34 (0.34, 0.34) 0.5 (0.5, 0.5) 0.36 (0.36, 0.36)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.17 (0.17, 0.17) 0.092 (0.092, 0.092) NA (NA, NA) 0.165 (0.165, 0.165) 0.301 (0.301, 0.301) 0.565 (0.565, 0.565) 0.078 (0.078, 0.078) 0.592 (0.592, 0.592)
Hormone_therapies count 63 63 63 63 63 63 63 63
time 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33) 23 (11, 33)
n 14 (8, 32) 8 (3, 22) 2 (1, 5) 2 (0, 7) 4 (1, 10) 3 (1, 7) 2 (0, 6) 2 (1, 6)
post_p 0.3 (0.12, 0.47) 0.36 (0.12, 0.48) 0.35 (0.2, 0.47) 0.36 (0.21, 0.47) 0.36 (0.22, 0.47) 0.36 (0.22, 0.48) 0.37 (0.2, 0.45) 0.34 (0.17, 0.46)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.142 (0.111, 0.217) 0.139 (0.097, 0.316) 0.172 (0.066, 0.67) 0.153 (0.082, 0.595) 0.171 (0.097, 0.83) 0.176 (0.1, 0.546) 0.175 (0.075, 0.397) 0.181 (0.09, 0.828)
Niraparib count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 6 (6, 6) 2 (2, 2) 4 (4, 4) 3 (3, 3) 3 (3, 3) 1 (1, 1) 3 (3, 3) 3 (3, 3)
post_p 0.21 (0.21, 0.21) 0.28 (0.28, 0.28) 0.44 (0.44, 0.44) 0.33 (0.33, 0.33) 0.4 (0.4, 0.4) 0.21 (0.21, 0.21) 0.48 (0.48, 0.48) 0.46 (0.46, 0.46)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.195 (0.195, 0.195) 0.365 (0.365, 0.365) 0.077 (0.077, 0.077) 0.139 (0.139, 0.139) 0.277 (0.277, 0.277) 0.36 (0.36, 0.36) 0 (0, 0) 0.086 (0.086, 0.086)
Taxel_therapies count 63 63 63 63 63 63 63 63
time 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32) 19 (10, 32)
n 9 (5, 25) 11 (5, 19) 2 (0, 4) 2 (0, 5) 4 (2, 9) 4 (1, 9) 2 (0, 6) 2 (0, 5)
post_p 0.28 (0.16, 0.45) 0.37 (0.17, 0.48) 0.36 (0.22, 0.47) 0.33 (0.15, 0.48) 0.36 (0.17, 0.46) 0.35 (0.19, 0.45) 0.35 (0.22, 0.48) 0.39 (0.2, 0.5)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.146 (0.103, 0.254) 0.143 (0.103, 0.241) 0.162 (0.069, 0.646) 0.171 (0.078, 0.503) 0.162 (0.11, 0.422) 0.177 (0.102, 0.42) 0.159 (0.069, 0.531) 0.141 (0.062, 0.552)