Carboplatin more effective in the DRD+ biomarker signature
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.075, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 13.1, median = 9.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1.49, hr = 0.66 |
|
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The overall error was 0.372.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.094 0.076 0.136 0.130
The overall power was 0.786.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.000 0.000 0.534 0.560
| signature | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| all | graduation | 16 | 0 | 10 | 10 | 1 |
| futility | 0 | 0 | 17 | 0 | 2 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 184 (109, 254) | 430 (397, 463) | 176 (109, 252) | 184 (117, 256) | 181 (121, 262) | |
| n_unique | 170 (98, 239) | 394 (364, 424) | 162 (100, 235) | 169 (107, 238) | 169 (110, 247) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 7 (6, 24) | NA (NA, NA) | 5 (4, 33) | 10 (7, 29) | 21 (7, 23) | |
| post_p | 1 (1, 1) | NA (NA, NA) | 0.41 (0.06, 0.84) | 1 (1, 1) | 0.46 (0.08, 0.85) | |
| rate | 0.072 (0.062, 0.084) | 0.112 (0.105, 0.12) | 0.114 (0.103, 0.129) | 0.072 (0.062, 0.085) | 0.112 (0.102, 0.126) | |
| DRD+ | graduation | 267 | 0 | 0 | 280 | 1 |
| futility | 0 | 0 | 78 | 0 | 92 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 67 (27, 102) | 118 (101, 135) | 34 (19, 63) | 65 (27, 103) | 36 (24, 63) | |
| n_unique | 62 (25, 95) | 107 (90, 123) | 30 (17, 56) | 60 (25, 96) | 32 (22, 57) | |
| time_trial | 34 (12, 36) | 36 (36, 36) | 36 (31, 36) | 32 (12, 36) | 36 (28, 36) | |
| time_stop | 19 (11, 32) | NA (NA, NA) | 29 (22, 35) | 18 (10, 32) | 28 (21, 33) | |
| post_p | 1 (1, 1) | NA (NA, NA) | 0.36 (0.07, 0.77) | 1 (1, 1) | 0.36 (0.08, 0.8) | |
| rate | 0.036 (0.029, 0.045) | 0.112 (0.098, 0.126) | 0.115 (0.092, 0.152) | 0.036 (0.028, 0.044) | 0.114 (0.09, 0.145) | |
| TEfus+ | graduation | 31 | 0 | 2 | 41 | 4 |
| futility | 0 | 0 | 59 | 0 | 68 | |
| max_n | 0 | 0 | 0 | 2 | 0 | |
| n | 70 (37, 105) | 157 (139, 177) | 63 (31, 91) | 68 (40, 103) | 72 (40, 101) | |
| n_unique | 64 (34, 98) | 143 (126, 161) | 57 (29, 84) | 63 (37, 95) | 67 (37, 92) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (30, 36) | 36 (36, 36) | 36 (27, 36) | |
| time_stop | 14 (11, 20) | NA (NA, NA) | 23 (16, 32) | 15 (11, 28) | 23 (10, 32) | |
| post_p | 1 (0.94, 1) | NA (NA, NA) | 0.4 (0.07, 0.82) | 1 (0.95, 1) | 0.39 (0.07, 0.8) | |
| rate | 0.064 (0.051, 0.082) | 0.112 (0.1, 0.125) | 0.114 (0.095, 0.144) | 0.065 (0.049, 0.079) | 0.115 (0.097, 0.136) | |
| TP53- & AR- | graduation | 123 | 0 | 30 | 133 | 31 |
| futility | 8 | 0 | 220 | 2 | 185 | |
| max_n | 11 | 0 | 18 | 13 | 15 | |
| n | 62 (27, 124) | 180 (155, 205) | 58 (26, 133) | 65 (28, 125) | 64 (26, 128) | |
| n_unique | 57 (25, 116) | 166 (142, 188) | 55 (25, 126) | 59 (26, 117) | 59 (24, 121) | |
| time_trial | 36 (14, 36) | 36 (36, 36) | 36 (10, 36) | 36 (15, 36) | 36 (16, 36) | |
| time_stop | 16 (10, 30) | NA (NA, NA) | 16 (7, 29) | 18 (10, 31) | 20 (12, 32) | |
| post_p | 0.99 (0.81, 1) | NA (NA, NA) | 0.41 (0.06, 0.83) | 0.99 (0.82, 1) | 0.42 (0.08, 0.87) | |
| rate | 0.072 (0.053, 0.093) | 0.112 (0.101, 0.126) | 0.117 (0.097, 0.146) | 0.074 (0.052, 0.095) | 0.114 (0.097, 0.149) | |
| TP53+ | graduation | 24 | 0 | 5 | 27 | 2 |
| futility | 1 | 0 | 63 | 1 | 63 | |
| max_n | 8 | 0 | 6 | 8 | 14 | |
| n | 86 (47, 125) | 190 (167, 211) | 82 (37, 124) | 83 (47, 124) | 86 (46, 126) | |
| n_unique | 78 (42, 119) | 172 (152, 193) | 76 (34, 115) | 78 (42, 114) | 79 (40, 118) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (29, 36) | 36 (36, 36) | 36 (26, 36) | |
| time_stop | 13 (9, 22) | NA (NA, NA) | 22 (9, 32) | 16 (10, 32) | 19 (10, 32) | |
| post_p | 0.99 (0.84, 1) | NA (NA, NA) | 0.4 (0.06, 0.84) | 0.99 (0.84, 1) | 0.4 (0.07, 0.87) | |
| rate | 0.075 (0.06, 0.093) | 0.112 (0.101, 0.124) | 0.113 (0.099, 0.141) | 0.075 (0.059, 0.093) | 0.114 (0.097, 0.138) |
| subtype | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| —- | graduation | 144 | 0 | 273 | 142 | 217 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 11 | 0 | 18 | 13 | 15 | |
| n | 27 (9, 84) | 114 (93, 135) | 35 (16, 102) | 29 (10, 89) | 36 (12, 95) | |
| n_unique | 25 (8, 80) | 106 (86, 126) | 33 (16, 98) | 26 (8, 84) | 34 (10, 90) | |
| post_p | 0.46 (0.1, 0.89) | NA (NA, NA) | 0.44 (0.1, 0.87) | 0.48 (0.08, 0.88) | 0.46 (0.1, 0.87) | |
| rate | 0.117 (0.09, 0.186) | 0.113 (0.099, 0.131) | 0.118 (0.097, 0.159) | 0.115 (0.092, 0.179) | 0.116 (0.095, 0.175) | |
| —+ | graduation | 167 | 0 | 294 | 167 | 248 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 11 | 0 | 18 | 14 | 14 | |
| n | 6 (2, 17) | 22 (15, 30) | 7 (2, 20) | 6 (2, 18) | 8 (3, 22) | |
| n_unique | 5 (1, 17) | 20 (14, 27) | 6 (2, 19) | 5 (1, 16) | 8 (3, 20) | |
| post_p | 0.47 (0.18, 0.82) | NA (NA, NA) | 0.43 (0.18, 0.81) | 0.44 (0.18, 0.81) | 0.44 (0.16, 0.85) | |
| rate | 0.12 (0.072, 0.279) | 0.113 (0.081, 0.156) | 0.128 (0.08, 0.289) | 0.125 (0.071, 0.326) | 0.125 (0.081, 0.272) | |
| –+- | graduation | 39 | 0 | 90 | 37 | 66 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 6 | 8 | 14 | |
| n | 22 (6, 50) | 63 (50, 77) | 28 (8, 60) | 23 (6, 53) | 24 (7, 55) | |
| n_unique | 20 (5, 47) | 57 (45, 72) | 26 (8, 56) | 21 (6, 49) | 22 (6, 52) | |
| post_p | 0.44 (0.12, 0.87) | NA (NA, NA) | 0.45 (0.11, 0.87) | 0.45 (0.1, 0.88) | 0.41 (0.1, 0.86) | |
| rate | 0.118 (0.09, 0.21) | 0.113 (0.093, 0.138) | 0.119 (0.092, 0.181) | 0.118 (0.089, 0.218) | 0.121 (0.091, 0.206) | |
| –++ | graduation | 63 | 0 | 127 | 66 | 121 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 6 | 10 | 13 | |
| n | 15 (4, 35) | 42 (33, 53) | 16 (4, 37) | 13 (4, 33) | 21 (7, 43) | |
| n_unique | 14 (3, 33) | 39 (30, 49) | 15 (4, 35) | 12 (3, 31) | 19 (6, 40) | |
| post_p | 0.5 (0.15, 0.85) | NA (NA, NA) | 0.43 (0.13, 0.84) | 0.44 (0.13, 0.84) | 0.45 (0.11, 0.87) | |
| rate | 0.115 (0.085, 0.226) | 0.112 (0.089, 0.143) | 0.121 (0.088, 0.261) | 0.124 (0.085, 0.252) | 0.119 (0.09, 0.22) | |
| -+– | graduation | 332 | 0 | 313 | 333 | 264 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 10 | 0 | 18 | 12 | 15 | |
| n | 10 (3, 22) | 21 (14, 29) | 4 (0, 13) | 10 (3, 22) | 5 (2, 14) | |
| n_unique | 9 (3, 21) | 19 (13, 26) | 4 (0, 12) | 9 (3, 21) | 5 (2, 13) | |
| post_p | 0.96 (0.63, 1) | NA (NA, NA) | 0.36 (0.14, 0.66) | 0.95 (0.7, 1) | 0.34 (0.15, 0.66) | |
| rate | 0.037 (0.02, 0.07) | 0.114 (0.084, 0.151) | 0.126 (0.072, 0.406) | 0.038 (0.021, 0.067) | 0.125 (0.071, 0.34) | |
| -+-+ | graduation | 337 | 0 | 328 | 338 | 288 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 10 | 0 | 18 | 13 | 14 | |
| n | 10 (3, 23) | 21 (15, 28) | 4 (0, 13) | 10 (3, 23) | 5 (1, 14) | |
| n_unique | 9 (3, 22) | 19 (13, 26) | 3 (0, 12) | 9 (3, 21) | 4 (1, 13) | |
| post_p | 0.95 (0.69, 1) | NA (NA, NA) | 0.35 (0.17, 0.65) | 0.96 (0.72, 1) | 0.32 (0.13, 0.67) | |
| rate | 0.036 (0.018, 0.066) | 0.112 (0.083, 0.151) | 0.133 (0.073, 0.405) | 0.036 (0.019, 0.066) | 0.128 (0.072, 0.365) | |
| -++- | graduation | 282 | 0 | 152 | 293 | 149 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 6 | 7 | 13 | |
| n | 6 (2, 14) | 12 (8, 18) | 3 (1, 9) | 6 (2, 13) | 4 (1, 9) | |
| n_unique | 6 (1, 13) | 11 (7, 17) | 3 (0, 8) | 5 (1, 12) | 3 (1, 8) | |
| post_p | 0.87 (0.5, 0.99) | NA (NA, NA) | 0.34 (0.16, 0.65) | 0.86 (0.5, 0.99) | 0.36 (0.18, 0.63) | |
| rate | 0.038 (0.016, 0.095) | 0.114 (0.074, 0.175) | 0.139 (0.068, 0.51) | 0.036 (0.015, 0.1) | 0.133 (0.065, 0.474) | |
| -+++ | graduation | 287 | 0 | 183 | 299 | 190 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 6 | 9 | 13 | |
| n | 6 (1, 14) | 12 (8, 18) | 4 (1, 10) | 6 (2, 14) | 4 (1, 9) | |
| n_unique | 6 (1, 13) | 11 (7, 16) | 3 (1, 9) | 5 (1, 13) | 3 (1, 8) | |
| post_p | 0.88 (0.49, 0.99) | NA (NA, NA) | 0.36 (0.18, 0.65) | 0.86 (0.49, 0.99) | 0.36 (0.17, 0.65) | |
| rate | 0.038 (0.013, 0.099) | 0.113 (0.076, 0.171) | 0.131 (0.068, 0.426) | 0.038 (0.013, 0.094) | 0.133 (0.064, 0.351) | |
| +— | graduation | 16 | 0 | 27 | 10 | 3 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (2, 18) | 20 (14, 27) | 8 (2, 18) | 8 (3, 17) | 11 (4, 21) | |
| n_unique | 7 (2, 16) | 18 (13, 24) | 7 (2, 17) | 7 (2, 15) | 10 (4, 20) | |
| post_p | 0.47 (0.19, 0.85) | NA (NA, NA) | 0.42 (0.18, 0.84) | 0.46 (0.18, 0.85) | 0.49 (0.16, 0.81) | |
| rate | 0.124 (0.073, 0.294) | 0.117 (0.085, 0.16) | 0.129 (0.078, 0.316) | 0.124 (0.072, 0.349) | 0.121 (0.082, 0.258) | |
| +–+ | graduation | 46 | 0 | 84 | 46 | 73 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 2 | 0 | |
| n | 6 (2, 13) | 16 (11, 22) | 7 (2, 16) | 6 (2, 14) | 8 (3, 18) | |
| n_unique | 5 (1, 12) | 15 (10, 21) | 6 (2, 15) | 5 (2, 13) | 8 (3, 16) | |
| post_p | 0.45 (0.2, 0.84) | NA (NA, NA) | 0.43 (0.18, 0.83) | 0.48 (0.2, 0.81) | 0.44 (0.17, 0.86) | |
| rate | 0.131 (0.071, 0.428) | 0.116 (0.079, 0.166) | 0.132 (0.075, 0.406) | 0.125 (0.068, 0.37) | 0.127 (0.073, 0.268) | |
| +-+- | graduation | 39 | 0 | 90 | 37 | 66 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 6 | 8 | 14 | |
| n | 6 (2, 15) | 16 (11, 22) | 6 (1, 15) | 6 (2, 14) | 8 (2, 16) | |
| n_unique | 5 (1, 13) | 15 (10, 20) | 6 (1, 14) | 5 (2, 13) | 7 (2, 15) | |
| post_p | 0.46 (0.2, 0.82) | NA (NA, NA) | 0.44 (0.2, 0.84) | 0.45 (0.19, 0.82) | 0.46 (0.18, 0.83) | |
| rate | 0.125 (0.071, 0.388) | 0.114 (0.08, 0.167) | 0.128 (0.072, 0.361) | 0.125 (0.073, 0.371) | 0.123 (0.074, 0.328) | |
| +-++ | graduation | 63 | 0 | 127 | 66 | 121 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 6 | 10 | 13 | |
| n | 6 (2, 14) | 17 (11, 22) | 6 (2, 15) | 6 (2, 14) | 8 (3, 17) | |
| n_unique | 5 (1, 13) | 15 (10, 20) | 5 (2, 14) | 6 (2, 13) | 8 (2, 16) | |
| post_p | 0.45 (0.2, 0.81) | NA (NA, NA) | 0.42 (0.19, 0.83) | 0.49 (0.22, 0.84) | 0.47 (0.19, 0.84) | |
| rate | 0.13 (0.075, 0.321) | 0.113 (0.079, 0.167) | 0.134 (0.072, 0.354) | 0.118 (0.071, 0.337) | 0.122 (0.079, 0.311) | |
| ++– | graduation | 278 | 0 | 102 | 285 | 95 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 14) | 12 (8, 17) | 3 (1, 9) | 6 (2, 14) | 3 (1, 9) | |
| n_unique | 6 (2, 13) | 11 (7, 16) | 3 (1, 8) | 5 (2, 13) | 3 (1, 8) | |
| post_p | 0.88 (0.51, 0.99) | NA (NA, NA) | 0.36 (0.17, 0.66) | 0.87 (0.48, 0.99) | 0.36 (0.19, 0.68) | |
| rate | 0.037 (0.014, 0.095) | 0.115 (0.075, 0.178) | 0.132 (0.062, 0.439) | 0.037 (0.014, 0.1) | 0.13 (0.063, 0.445) | |
| ++-+ | graduation | 284 | 0 | 148 | 292 | 149 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 2 | 0 | |
| n | 6 (2, 14) | 12 (8, 17) | 4 (1, 9) | 6 (2, 14) | 4 (1, 8) | |
| n_unique | 5 (2, 13) | 11 (7, 16) | 3 (1, 8) | 6 (1, 13) | 3 (1, 8) | |
| post_p | 0.86 (0.51, 0.98) | NA (NA, NA) | 0.35 (0.16, 0.67) | 0.89 (0.57, 0.98) | 0.35 (0.18, 0.64) | |
| rate | 0.037 (0.015, 0.093) | 0.112 (0.073, 0.171) | 0.131 (0.061, 0.39) | 0.036 (0.014, 0.08) | 0.136 (0.063, 0.397) | |
| +++- | graduation | 282 | 0 | 152 | 293 | 149 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 6 | 7 | 13 | |
| n | 6 (2, 14) | 12 (8, 17) | 3 (1, 9) | 6 (2, 14) | 4 (1, 9) | |
| n_unique | 6 (1, 13) | 11 (7, 16) | 3 (1, 9) | 5 (1, 13) | 3 (1, 8) | |
| post_p | 0.85 (0.54, 0.98) | NA (NA, NA) | 0.36 (0.16, 0.65) | 0.87 (0.52, 0.99) | 0.36 (0.18, 0.65) | |
| rate | 0.038 (0.017, 0.085) | 0.112 (0.074, 0.179) | 0.129 (0.059, 0.333) | 0.035 (0.014, 0.087) | 0.129 (0.062, 0.392) | |
| ++++ | graduation | 287 | 0 | 183 | 299 | 190 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 7 | 0 | 6 | 9 | 13 | |
| n | 5 (2, 13) | 12 (8, 18) | 4 (1, 9) | 6 (2, 14) | 3 (1, 9) | |
| n_unique | 5 (1, 13) | 11 (7, 16) | 3 (1, 8) | 5 (1, 13) | 3 (1, 9) | |
| post_p | 0.86 (0.49, 0.98) | NA (NA, NA) | 0.38 (0.18, 0.69) | 0.88 (0.47, 0.98) | 0.36 (0.17, 0.64) | |
| rate | 0.038 (0.015, 0.097) | 0.11 (0.071, 0.177) | 0.122 (0.057, 0.386) | 0.037 (0.015, 0.092) | 0.132 (0.061, 0.431) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 10 | 1 | 16 | 10 |
| time_stop | 5 (4, 6) | 4 (4, 4) | 7 (6, 24) | 10 (7, 29) | |
| n_trt | 31 (29, 41) | 25 (25, 25) | 36 (28, 130) | 50 (36, 118) | |
| n_control | 56 (51, 70) | 43 (43, 43) | 76 (60, 300) | 108 (78, 348) | |
| post_p | 0.89 (0.86, 0.93) | 0.88 (0.88, 0.88) | 1 (0.97, 1) | 1 (0.98, 1) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 3.5) | 1 (1, 6) | |
| TP53- & AR- | count | 30 | 31 | 123 | 133 |
| time_stop | 9 (6, 15) | 15 (11, 23) | 15 (10, 30) | 18 (10, 31) | |
| n_trt | 30 (26, 46) | 36 (27, 56) | 33 (26, 77) | 41 (25, 93) | |
| n_control | 43 (27, 67) | 63 (51, 111) | 69 (41, 149) | 79 (46, 148) | |
| post_p | 0.9 (0.86, 0.96) | 0.92 (0.88, 0.96) | 0.98 (0.91, 1) | 0.99 (0.92, 1) | |
| order | 1 (1, 1.1) | 1 (1, 3) | 2 (1, 3) | 2 (1, 3) | |
| TP53+ | count | 5 | 2 | 24 | 27 |
| time_stop | 9 (8, 10) | 8 (7, 10) | 13 (9, 22) | 16 (10, 32) | |
| n_trt | 29 (26, 30) | 26 (25, 28) | 33 (26, 60) | 39 (27, 103) | |
| n_control | 38 (33, 44) | 46 (38, 54) | 64 (41, 109) | 73 (41, 176) | |
| post_p | 0.95 (0.92, 0.97) | 0.9 (0.9, 0.9) | 1 (0.94, 1) | 1 (0.94, 1) | |
| order | 1 (1, 1) | 1.5 (1.1, 1.9) | 2 (1, 3.7) | 2 (1, 3.4) | |
| DRD+ | count | 1 | 267 | 280 | |
| time_stop | 21 (21, 21) | 19 (11, 32) | 18 (10, 32) | ||
| n_trt | 25 (25, 25) | 41 (26, 83) | 42 (26, 86) | ||
| n_control | 69 (69, 69) | 57 (28, 100) | 50 (27, 108) | ||
| post_p | 0.98 (0.98, 0.98) | 1 (0.98, 1) | 1 (0.98, 1) | ||
| order | 1 (1, 1) | 2 (1, 4) | 2 (1, 3) | ||
| TEfus+ | count | 2 | 4 | 31 | 41 |
| time_stop | 12 (11, 13) | 10 (9, 11) | 14 (11, 20) | 15 (11, 28) | |
| n_trt | 30 (28, 32) | 28 (25, 31) | 28 (25, 42) | 29 (25, 67) | |
| n_control | 50 (45, 54) | 32 (31, 42) | 51 (42, 79) | 57 (40, 103) | |
| post_p | 0.96 (0.94, 0.97) | 0.94 (0.88, 0.95) | 1 (0.95, 1) | 1 (0.97, 1) | |
| order | 1.5 (1.1, 1.9) | 1 (1, 1) | 2 (1, 3) | 2 (1, 4) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 17 | 2 | ||
| time_stop | 5 (4, 35) | 22 (21, 24) | |||
| n_trt | 31 (25, 135) | 98 (80, 116) | |||
| n_control | 50 (37, 411) | 258 (244, 271) | |||
| post_p | 0.08 (0, 0.18) | 0.01 (0.01, 0.02) | |||
| order | 1 (1, 4.4) | 4.5 (4.1, 4.9) | |||
| TP53- & AR- | count | 220 | 185 | 8 | 2 |
| time_stop | 16 (8, 30) | 21 (13, 32) | 17 (15, 24) | 17 (15, 19) | |
| n_trt | 38 (26, 74) | 35 (25, 80) | 34 (28, 66) | 44 (29, 58) | |
| n_control | 74 (32, 148) | 101 (55, 162) | 71 (60, 140) | 89 (75, 103) | |
| post_p | 0.15 (0.05, 0.27) | 0.16 (0.05, 0.27) | 0.17 (0.12, 0.27) | 0.16 (0.13, 0.19) | |
| order | 1 (1, 2) | 2 (1, 3) | 2 (1, 3.3) | 2 (1.2, 2.8) | |
| TP53+ | count | 63 | 63 | 1 | 1 |
| time_stop | 23 (11, 33) | 19 (10, 32) | 11 (11, 11) | 10 (10, 10) | |
| n_trt | 41 (26, 77) | 38 (26, 68) | 26 (26, 26) | 25 (25, 25) | |
| n_control | 113 (46, 178) | 88 (38, 174) | 40 (40, 40) | 39 (39, 39) | |
| post_p | 0.08 (0.01, 0.24) | 0.08 (0.01, 0.22) | 0.13 (0.13, 0.13) | 0.09 (0.09, 0.09) | |
| order | 2 (1, 4) | 1 (1, 3) | 1 (1, 1) | 1 (1, 1) | |
| DRD+ | count | 78 | 92 | ||
| time_stop | 29 (22, 35) | 28 (21, 33) | |||
| n_trt | 31 (25, 47) | 29 (25, 50) | |||
| n_control | 91 (66, 112) | 90 (59, 117) | |||
| post_p | 0.08 (0.02, 0.24) | 0.1 (0.02, 0.22) | |||
| order | 2 (1, 4) | 2 (1, 4) | |||
| TEfus+ | count | 59 | 68 | ||
| time_stop | 23 (16, 32) | 23 (13, 32) | |||
| n_trt | 35 (26, 55) | 40 (27, 64) | |||
| n_control | 94 (60, 142) | 91 (46, 140) | |||
| post_p | 0.07 (0.01, 0.19) | 0.06 (0.02, 0.21) | |||
| order | 2 (1, 4) | 2 (1, 4) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 | 16 |
| time | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | 7 (6, 24) | ||
| n | 8 (2, 26) | 2 (0, 6) | 6 (3, 20) | 3 (0, 14) | 4 (0, 8) | 3 (1, 6) | 2 (0, 4) | 1 (0, 4) | 0 (0, 7) | 2 (0, 6) | 1 (0, 5) | 1 (0, 7) | 2 (0, 6) | 3 (1, 6) | 2 (1, 6) | 2 (0, 4) | ||
| post_p | 0.71 (0.6, 0.8) | 0.64 (0.55, 0.71) | 0.63 (0.53, 0.7) | 0.59 (0.56, 0.7) | 0.58 (0.5, 0.76) | 0.64 (0.54, 0.8) | 0.58 (0.53, 0.8) | 0.58 (0.52, 0.71) | 0.54 (0.51, 0.7) | 0.59 (0.54, 0.74) | 0.56 (0.51, 0.65) | 0.61 (0.51, 0.74) | 0.73 (0.55, 0.93) | 0.61 (0.53, 0.82) | 0.67 (0.53, 0.87) | 0.63 (0.51, 0.71) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.036 (0, 0.094) | 0 (0, 0.093) | 0.074 (0, 0.099) | 0.017 (0, 0.121) | 0 (0, 0.049) | 0 (0, 0.074) | 0 (0, 0.04) | 0 (0, 0.039) | 0 (0, 0.119) | 0 (0, 0.095) | 0 (0, 0.091) | 0 (0, 0.097) | 0 (0, 0.028) | 0 (0, 0.044) | 0 (0, 0.042) | 0 (0, 0.075) | ||
| Hormone_therapies | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |
| time | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | 5 (4, 6) | ||
| n | 15 (13, 16) | 2 (1, 5) | 8 (6, 10) | 4 (1, 7) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 2) | 0 (0, 3) | 2 (0, 3) | 0 (0, 1) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | ||
| post_p | 0.74 (0.64, 0.93) | 0.6 (0.52, 0.65) | 0.68 (0.6, 0.78) | 0.7 (0.54, 0.75) | NA (NA, NA) | 0.53 (0.51, 0.59) | 0.51 (0.51, 0.51) | 0.54 (0.53, 0.55) | 0.65 (0.57, 0.7) | 0.64 (0.52, 0.74) | 0.56 (0.55, 0.6) | 0.57 (0.53, 0.6) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.52 (0.52, 0.52) | 0.51 (0.5, 0.53) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.045 (0.023, 0.073) | 0.043 (0, 0.204) | 0.039 (0, 0.08) | 0 (0, 0.113) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.125) | 0 (0, 0) | 0 (0, 0.099) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Niraparib | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |
| time | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | 10 (7, 29) | ||
| n | 11 (4, 31) | 2 (0, 4) | 8 (5, 24) | 4 (2, 13) | 3 (0, 8) | 6 (5, 7) | 2 (1, 6) | 3 (1, 4) | 2 (0, 13) | 0 (0, 4) | 1 (1, 6) | 2 (0, 3) | 2 (1, 4) | 3 (1, 5) | 3 (2, 4) | 2 (0, 4) | ||
| post_p | 0.65 (0.5, 0.84) | 0.7 (0.54, 0.81) | 0.6 (0.55, 0.88) | 0.68 (0.61, 0.86) | 0.7 (0.56, 0.95) | 0.73 (0.61, 0.96) | 0.67 (0.6, 0.8) | 0.64 (0.53, 0.77) | 0.58 (0.51, 0.75) | 0.57 (0.55, 0.6) | 0.56 (0.5, 0.69) | 0.56 (0.52, 0.8) | 0.76 (0.56, 0.96) | 0.61 (0.52, 0.89) | 0.69 (0.59, 0.81) | 0.7 (0.51, 0.89) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.09 (0.028, 0.116) | 0.059 (0, 0.08) | 0.097 (0, 0.127) | 0.027 (0, 0.069) | 0.025 (0, 0.033) | 0.032 (0, 0.066) | 0 (0, 0.053) | 0.039 (0, 0.089) | 0.046 (0, 0.099) | 0.072 (0.026, 0.091) | 0 (0, 0.134) | 0 (0, 0.108) | 0 (0, 0.022) | 0.004 (0, 0.11) | 0.025 (0, 0.069) | 0 (0, 0.025) | ||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 5 (5, 5) | 0 (0, 0) | 7 (7, 7) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 2 (2, 2) | 5 (5, 5) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.76 (0.76, 0.76) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.76 (0.76, 0.76) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.58 (0.58, 0.58) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.12 (0.12, 0.12) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.069 (0.069, 0.069) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| DRD+ | Carboplatin | count | 267 | 267 | 267 | 267 | 267 | 267 | 267 | 267 | ||||||||
| time | 19 (11, 32) | 19 (11, 32) | 19 (11, 32) | 19 (11, 32) | 19 (11, 32) | 19 (11, 32) | 19 (11, 32) | 19 (11, 32) | ||||||||||
| n | 7 (3, 17) | 8 (3, 16) | 5 (2, 11) | 5 (1, 11) | 4 (1, 10) | 4 (2, 11) | 4 (1, 11) | 4 (1, 11) | ||||||||||
| post_p | 0.81 (0.6, 0.97) | 0.81 (0.62, 0.97) | 0.74 (0.56, 0.95) | 0.74 (0.53, 0.94) | 0.74 (0.54, 0.93) | 0.75 (0.54, 0.94) | 0.74 (0.55, 0.93) | 0.74 (0.54, 0.95) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.035 (0, 0.064) | 0.033 (0, 0.064) | 0.028 (0, 0.068) | 0.03 (0, 0.071) | 0.029 (0, 0.074) | 0.029 (0, 0.077) | 0.031 (0, 0.068) | 0.028 (0, 0.068) | ||||||||||
| Niraparib | count | 280 | 280 | 280 | 280 | 280 | 280 | 280 | 280 | |||||||||
| time | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | 18 (10, 32) | ||||||||||
| n | 7 (3, 16) | 8 (3, 17) | 4 (1, 11) | 4 (1, 10) | 4 (1, 11) | 4 (1, 11) | 4 (2, 11) | 4 (1, 11) | ||||||||||
| post_p | 0.8 (0.59, 0.98) | 0.82 (0.62, 0.98) | 0.74 (0.54, 0.93) | 0.72 (0.54, 0.93) | 0.74 (0.54, 0.93) | 0.76 (0.56, 0.94) | 0.72 (0.53, 0.92) | 0.75 (0.54, 0.95) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.032 (0, 0.07) | 0.029 (0, 0.06) | 0.028 (0, 0.071) | 0.03 (0, 0.072) | 0.028 (0, 0.07) | 0.027 (0, 0.068) | 0.029 (0, 0.072) | 0.026 (0, 0.068) | ||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | ||||||||||
| n | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 0 (0, 0) | 1 (1, 1) | 5 (5, 5) | 3 (3, 3) | 4 (4, 4) | ||||||||||
| post_p | 0.67 (0.67, 0.67) | 0.54 (0.54, 0.54) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.84 (0.84, 0.84) | 0.87 (0.87, 0.87) | 0.5 (0.5, 0.5) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.06 (0.06, 0.06) | 0.114 (0.114, 0.114) | 0.081 (0.081, 0.081) | NA (NA, NA) | 0 (0, 0) | 0.039 (0.039, 0.039) | 0 (0, 0) | 0.07 (0.07, 0.07) | ||||||||||
| TEfus+ | Carboplatin | count | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | ||||||||
| time | 14 (11, 20) | 14 (11, 20) | 14 (11, 20) | 14 (11, 20) | 14 (11, 20) | 14 (11, 20) | 14 (11, 20) | 14 (11, 20) | ||||||||||
| n | 3 (1, 5) | 6 (3, 14) | 5 (4, 8) | 3 (2, 6) | 2 (1, 5) | 3 (1, 7) | 3 (1, 5) | 4 (1, 5) | ||||||||||
| post_p | 0.61 (0.51, 0.73) | 0.73 (0.53, 0.8) | 0.77 (0.61, 0.92) | 0.73 (0.55, 0.91) | 0.61 (0.53, 0.85) | 0.68 (0.54, 0.8) | 0.68 (0.58, 0.82) | 0.7 (0.53, 0.85) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.071 (0, 0.127) | 0.075 (0.04, 0.1) | 0.03 (0, 0.061) | 0 (0, 0.064) | 0.036 (0, 0.115) | 0.045 (0, 0.117) | 0.031 (0, 0.087) | 0.008 (0, 0.076) | ||||||||||
| Hormone_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | ||||||||||
| n | 6 (3, 8) | 14 (10, 18) | 1 (0, 2) | 2 (0, 3) | 2 (1, 4) | 3 (2, 4) | 2 (1, 2) | 2 (0, 3) | ||||||||||
| post_p | 0.75 (0.69, 0.81) | 0.87 (0.83, 0.91) | 0.69 (0.69, 0.69) | 0.5 (0.5, 0.5) | 0.66 (0.61, 0.71) | 0.52 (0.51, 0.52) | 0.54 (0.54, 0.54) | 0.59 (0.59, 0.59) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.017 (0.003, 0.031) | 0.055 (0.05, 0.061) | 0 (0, 0) | 0 (0, 0) | 0.031 (0.006, 0.056) | 0.025 (0.005, 0.045) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| Niraparib | count | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | |||||||||
| time | 15 (11, 28) | 15 (11, 28) | 15 (11, 28) | 15 (11, 28) | 15 (11, 28) | 15 (11, 28) | 15 (11, 28) | 15 (11, 28) | ||||||||||
| n | 3 (1, 7) | 7 (3, 18) | 7 (4, 12) | 3 (2, 7) | 3 (1, 7) | 3 (0, 7) | 4 (1, 8) | 3 (1, 8) | ||||||||||
| post_p | 0.64 (0.53, 0.84) | 0.75 (0.6, 0.86) | 0.83 (0.72, 0.94) | 0.72 (0.54, 0.89) | 0.6 (0.52, 0.84) | 0.67 (0.55, 0.81) | 0.71 (0.52, 0.88) | 0.7 (0.55, 0.92) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.059 (0, 0.098) | 0.066 (0, 0.097) | 0.019 (0, 0.054) | 0.023 (0, 0.069) | 0.033 (0, 0.12) | 0.065 (0, 0.113) | 0.029 (0, 0.086) | 0.014 (0, 0.07) | ||||||||||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | 10 (9, 11) | ||||||||||
| n | 4 (4, 5) | 8 (6, 13) | 1 (0, 3) | 1 (0, 2) | 4 (3, 6) | 3 (3, 4) | 2 (1, 4) | 2 (1, 2) | ||||||||||
| post_p | 0.68 (0.65, 0.74) | 0.81 (0.66, 0.95) | 0.58 (0.52, 0.72) | 0.52 (0.52, 0.53) | 0.7 (0.56, 0.94) | 0.7 (0.64, 0.75) | 0.54 (0.51, 0.64) | 0.53 (0.52, 0.61) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.054 (0.048, 0.096) | 0.085 (0.063, 0.088) | 0 (0, 0) | 0 (0, 0) | 0.043 (0, 0.086) | 0.1 (0.067, 0.145) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| TP53- & AR- | Carboplatin | count | 123 | 123 | 123 | 123 | ||||||||||||
| time | 15 (10, 30) | 15 (10, 30) | 15 (10, 30) | 15 (10, 30) | ||||||||||||||
| n | 19 (12, 48) | 3 (1, 8) | 6 (3, 15) | 6 (3, 15) | ||||||||||||||
| post_p | 0.78 (0.71, 0.91) | 0.61 (0.51, 0.79) | 0.79 (0.54, 0.98) | 0.78 (0.56, 0.98) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.076 (0.04, 0.103) | 0.068 (0, 0.114) | 0.031 (0, 0.071) | 0.03 (0, 0.066) | ||||||||||||||
| Hormone_therapies | count | 30 | 30 | 30 | 30 | |||||||||||||
| time | 9 (6, 15) | 9 (6, 15) | 9 (6, 15) | 9 (6, 15) | ||||||||||||||
| n | 24 (20, 34) | 3 (2, 8) | 1 (0, 5) | 1 (0, 3) | ||||||||||||||
| post_p | 0.89 (0.76, 0.96) | 0.63 (0.52, 0.85) | 0.62 (0.5, 0.74) | 0.55 (0.51, 0.68) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.067 (0.035, 0.102) | 0.056 (0, 0.121) | 0 (0, 0.07) | 0 (0, 0.071) | ||||||||||||||
| Niraparib | count | 133 | 133 | 133 | 133 | |||||||||||||
| time | 18 (10, 31) | 18 (10, 31) | 18 (10, 31) | 18 (10, 31) | ||||||||||||||
| n | 20 (12, 61) | 4 (1, 12) | 6 (3, 14) | 8 (3, 14) | ||||||||||||||
| post_p | 0.76 (0.71, 0.93) | 0.64 (0.51, 0.81) | 0.87 (0.62, 0.98) | 0.82 (0.67, 0.97) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.079 (0.047, 0.104) | 0.074 (0, 0.126) | 0.032 (0, 0.06) | 0.031 (0, 0.06) | ||||||||||||||
| Taxel_therapies | count | 31 | 31 | 31 | 31 | |||||||||||||
| time | 15 (11, 23) | 15 (11, 23) | 15 (11, 23) | 15 (11, 23) | ||||||||||||||
| n | 27 (16, 36) | 5 (2, 13) | 3 (0, 5) | 2 (0, 5) | ||||||||||||||
| post_p | 0.79 (0.73, 0.91) | 0.72 (0.54, 0.91) | 0.58 (0.51, 0.73) | 0.58 (0.52, 0.79) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.076 (0.056, 0.096) | 0.06 (0, 0.112) | 0.048 (0, 0.097) | 0.016 (0, 0.077) | ||||||||||||||
| TP53+ | Carboplatin | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | ||||||||
| time | 13 (9, 22) | 13 (9, 22) | 13 (9, 22) | 13 (9, 22) | 13 (9, 22) | 13 (9, 22) | 13 (9, 22) | 13 (9, 22) | ||||||||||
| n | 10 (4, 17) | 5 (1, 15) | 4 (1, 7) | 2 (1, 6) | 3 (1, 5) | 3 (0, 7) | 3 (1, 8) | 3 (1, 6) | ||||||||||
| post_p | 0.79 (0.55, 0.89) | 0.72 (0.54, 0.8) | 0.66 (0.56, 0.86) | 0.64 (0.54, 0.8) | 0.63 (0.53, 0.78) | 0.68 (0.56, 0.86) | 0.65 (0.54, 0.87) | 0.69 (0.56, 0.85) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.071 (0.008, 0.101) | 0.076 (0, 0.11) | 0 (0, 0.041) | 0.037 (0, 0.06) | 0.058 (0, 0.11) | 0.057 (0, 0.11) | 0 (0, 0.076) | 0 (0, 0.079) | ||||||||||
| Hormone_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | 9 (8, 10) | ||||||||||
| n | 16 (14, 19) | 4 (3, 7) | 2 (1, 3) | 0 (0, 2) | 2 (0, 3) | 1 (0, 3) | 1 (0, 2) | 0 (0, 1) | ||||||||||
| post_p | 0.86 (0.8, 0.94) | 0.73 (0.66, 0.78) | 0.58 (0.55, 0.61) | 0.6 (0.55, 0.64) | 0.6 (0.57, 0.76) | 0.59 (0.54, 0.66) | 0.54 (0.51, 0.57) | 0.5 (0.5, 0.5) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.041 (0.022, 0.071) | 0.048 (0, 0.063) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.081) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| Niraparib | count | 27 | 27 | 27 | 27 | 27 | 27 | 27 | 27 | |||||||||
| time | 16 (10, 32) | 16 (10, 32) | 16 (10, 32) | 16 (10, 32) | 16 (10, 32) | 16 (10, 32) | 16 (10, 32) | 16 (10, 32) | ||||||||||
| n | 16 (5, 34) | 7 (3, 22) | 4 (1, 7) | 3 (0, 7) | 3 (0, 11) | 2 (1, 10) | 4 (1, 11) | 3 (2, 7) | ||||||||||
| post_p | 0.75 (0.57, 0.91) | 0.71 (0.57, 0.9) | 0.78 (0.61, 0.91) | 0.69 (0.51, 0.87) | 0.7 (0.52, 0.89) | 0.63 (0.54, 0.88) | 0.74 (0.52, 0.95) | 0.72 (0.54, 0.89) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.086 (0.055, 0.107) | 0.08 (0.028, 0.112) | 0.03 (0, 0.085) | 0.032 (0, 0.078) | 0.056 (0, 0.104) | 0.067 (0, 0.111) | 0.027 (0, 0.07) | 0.014 (0, 0.065) | ||||||||||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 8 (7, 10) | 8 (7, 10) | 8 (7, 10) | 8 (7, 10) | 8 (7, 10) | 8 (7, 10) | 8 (7, 10) | 8 (7, 10) | ||||||||||
| n | 6 (3, 10) | 8 (5, 11) | 1 (1, 1) | 2 (0, 3) | 3 (3, 3) | 4 (3, 6) | 0 (0, 1) | 2 (1, 2) | ||||||||||
| post_p | 0.63 (0.56, 0.71) | 0.74 (0.73, 0.74) | 0.51 (0.5, 0.52) | 0.55 (0.55, 0.55) | 0.6 (0.56, 0.63) | 0.76 (0.63, 0.89) | 0.51 (0.51, 0.51) | 0.56 (0.55, 0.58) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.126 (0.098, 0.155) | 0.054 (0.011, 0.097) | 0 (0, 0) | 0 (0, 0) | 0.078 (0.061, 0.096) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 |
| time | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | 5 (4, 35) | ||
| n | 15 (11, 32) | 2 (1, 6) | 7 (4, 29) | 2 (1, 9) | 0 (0, 4) | 0 (0, 7) | 0 (0, 3) | 0 (0, 2) | 2 (0, 12) | 2 (0, 5) | 1 (0, 6) | 2 (0, 6) | 0 (0, 3) | 0 (0, 4) | 0 (0, 3) | 0 (0, 2) | ||
| post_p | 0.27 (0.05, 0.45) | 0.32 (0.23, 0.41) | 0.33 (0.16, 0.39) | 0.34 (0.26, 0.43) | 0.33 (0.17, 0.5) | 0.39 (0.29, 0.47) | 0.18 (0.16, 0.37) | 0.36 (0.31, 0.46) | 0.36 (0.19, 0.48) | 0.36 (0.25, 0.45) | 0.33 (0.22, 0.48) | 0.41 (0.37, 0.49) | 0.39 (0.26, 0.47) | 0.33 (0.27, 0.47) | 0.4 (0.13, 0.46) | 0.36 (0.33, 0.41) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.134 (0.078, 0.274) | 0.18 (0.041, 0.346) | 0.177 (0.117, 0.27) | 0.228 (0.054, 0.6) | 0.152 (0, 0.594) | 0.108 (0.097, 0.839) | 0.192 (0.06, 0.826) | 0.974 (0.082, 5.57) | 0.081 (0, 0.225) | 0.158 (0, 0.272) | 0.155 (0, 0.766) | 0.19 (0.041, 0.258) | 0.151 (0.076, 0.539) | 0.108 (0, 0.205) | 0.142 (0, 0.294) | 0.33 (0.124, 27.05) | ||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | 22 (21, 24) | ||
| n | 27 (21, 33) | 6 (4, 7) | 8 (6, 9) | 9 (4, 14) | 3 (2, 4) | 10 (5, 14) | 3 (2, 4) | 3 (2, 4) | 6 (5, 6) | 4 (4, 4) | 2 (2, 3) | 6 (5, 8) | 4 (2, 5) | 2 (1, 4) | 5 (3, 7) | 2 (1, 2) | ||
| post_p | 0.38 (0.35, 0.41) | 0.31 (0.29, 0.33) | 0.22 (0.22, 0.22) | 0.3 (0.19, 0.41) | 0.28 (0.27, 0.29) | 0.24 (0.2, 0.29) | 0.23 (0.2, 0.26) | 0.38 (0.37, 0.4) | 0.3 (0.15, 0.45) | 0.45 (0.44, 0.45) | 0.25 (0.17, 0.32) | 0.39 (0.38, 0.41) | 0.37 (0.3, 0.44) | 0.18 (0.08, 0.28) | 0.3 (0.22, 0.38) | 0.19 (0.06, 0.33) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.13 (0.123, 0.138) | 0.183 (0.156, 0.209) | 0.226 (0.199, 0.253) | 0.276 (0.167, 0.386) | 0.263 (0.176, 0.349) | 0.176 (0.143, 0.209) | 0.223 (0.202, 0.245) | 0.173 (0.123, 0.223) | 0.223 (0.142, 0.305) | 0.215 (0.207, 0.223) | 0.285 (0.26, 0.309) | 0.144 (0.127, 0.162) | 0.069 (0.065, 0.074) | 0.224 (0.174, 0.275) | 0.802 (0.26, 1.345) | 0.239 (0.236, 0.242) | ||
| DRD+ | Hormone_therapies | count | 78 | 78 | 78 | 78 | 78 | 78 | 78 | 78 | ||||||||
| time | 29 (22, 35) | 29 (22, 35) | 29 (22, 35) | 29 (22, 35) | 29 (22, 35) | 29 (22, 35) | 29 (22, 35) | 29 (22, 35) | ||||||||||
| n | 4 (2, 10) | 5 (1, 12) | 3 (1, 8) | 3 (1, 7) | 3 (1, 7) | 4 (1, 6) | 4 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.33 (0.12, 0.48) | 0.31 (0.17, 0.45) | 0.3 (0.16, 0.45) | 0.32 (0.18, 0.45) | 0.33 (0.18, 0.46) | 0.31 (0.16, 0.47) | 0.32 (0.15, 0.46) | 0.35 (0.19, 0.44) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.158 (0.091, 0.488) | 0.125 (0.087, 0.35) | 0.172 (0.083, 0.679) | 0.152 (0.089, 0.578) | 0.147 (0.092, 0.599) | 0.173 (0.101, 0.493) | 0.15 (0.093, 0.422) | 0.148 (0.093, 0.524) | ||||||||||
| Taxel_therapies | count | 92 | 92 | 92 | 92 | 92 | 92 | 92 | 92 | |||||||||
| time | 28 (21, 33) | 28 (21, 33) | 28 (21, 33) | 28 (21, 33) | 28 (21, 33) | 28 (21, 33) | 28 (21, 33) | 28 (21, 33) | ||||||||||
| n | 5 (2, 11) | 5 (2, 11) | 3 (1, 7) | 3 (1, 7) | 3 (1, 6) | 3 (1, 8) | 3 (1, 7) | 3 (1, 8) | ||||||||||
| post_p | 0.31 (0.17, 0.47) | 0.32 (0.13, 0.48) | 0.34 (0.2, 0.46) | 0.33 (0.15, 0.47) | 0.33 (0.17, 0.46) | 0.34 (0.16, 0.45) | 0.35 (0.19, 0.48) | 0.3 (0.14, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.133 (0.089, 0.302) | 0.143 (0.083, 0.37) | 0.16 (0.085, 0.473) | 0.144 (0.094, 0.51) | 0.167 (0.09, 1.203) | 0.139 (0.085, 0.447) | 0.157 (0.083, 0.424) | 0.153 (0.096, 0.646) | ||||||||||
| TEfus+ | Hormone_therapies | count | 59 | 59 | 59 | 59 | 59 | 59 | 59 | 59 | ||||||||
| time | 23 (16, 32) | 23 (16, 32) | 23 (16, 32) | 23 (16, 32) | 23 (16, 32) | 23 (16, 32) | 23 (16, 32) | 23 (16, 32) | ||||||||||
| n | 4 (2, 9) | 9 (4, 22) | 4 (0, 9) | 3 (0, 6) | 3 (1, 9) | 3 (1, 7) | 2 (1, 5) | 3 (1, 6) | ||||||||||
| post_p | 0.31 (0.12, 0.46) | 0.34 (0.14, 0.47) | 0.32 (0.16, 0.47) | 0.37 (0.22, 0.46) | 0.31 (0.18, 0.46) | 0.34 (0.2, 0.46) | 0.33 (0.21, 0.47) | 0.35 (0.18, 0.48) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.186 (0.112, 0.525) | 0.156 (0.111, 0.265) | 0.13 (0.087, 0.658) | 0.139 (0.076, 0.586) | 0.188 (0.108, 0.682) | 0.179 (0.107, 0.386) | 0.162 (0.086, 0.545) | 0.148 (0.077, 0.501) | ||||||||||
| Taxel_therapies | count | 68 | 68 | 68 | 68 | 68 | 68 | 68 | 68 | |||||||||
| time | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | 23 (13, 32) | ||||||||||
| n | 5 (2, 11) | 10 (6, 26) | 3 (1, 7) | 2 (1, 5) | 5 (2, 10) | 5 (2, 8) | 2 (1, 7) | 3 (0, 7) | ||||||||||
| post_p | 0.33 (0.13, 0.47) | 0.29 (0.1, 0.47) | 0.31 (0.16, 0.46) | 0.32 (0.18, 0.48) | 0.34 (0.19, 0.49) | 0.35 (0.17, 0.48) | 0.35 (0.16, 0.48) | 0.39 (0.18, 0.48) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.165 (0.112, 0.418) | 0.142 (0.102, 0.298) | 0.165 (0.082, 0.497) | 0.163 (0.076, 0.363) | 0.16 (0.095, 0.326) | 0.167 (0.099, 0.443) | 0.155 (0.079, 0.453) | 0.146 (0.063, 0.393) | ||||||||||
| TP53- & AR- | Carboplatin | count | 8 | 8 | 8 | 8 | ||||||||||||
| time | 17 (15, 24) | 17 (15, 24) | 17 (15, 24) | 17 (15, 24) | ||||||||||||||
| n | 24 (16, 42) | 3 (1, 12) | 4 (1, 7) | 4 (2, 12) | ||||||||||||||
| post_p | 0.28 (0.12, 0.44) | 0.39 (0.17, 0.44) | 0.29 (0.12, 0.43) | 0.41 (0.32, 0.46) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.14 (0.117, 0.189) | 0.164 (0.107, 0.225) | 0.212 (0.085, 0.539) | 0.118 (0.055, 0.288) | ||||||||||||||
| Hormone_therapies | count | 220 | 220 | 220 | 220 | |||||||||||||
| time | 16 (8, 30) | 16 (8, 30) | 16 (8, 30) | 16 (8, 30) | ||||||||||||||
| n | 24 (16, 56) | 5 (2, 11) | 3 (0, 8) | 3 (0, 7) | ||||||||||||||
| post_p | 0.32 (0.11, 0.47) | 0.38 (0.18, 0.49) | 0.35 (0.17, 0.48) | 0.36 (0.17, 0.48) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.128 (0.107, 0.173) | 0.153 (0.089, 0.349) | 0.139 (0.071, 0.538) | 0.141 (0.069, 0.58) | ||||||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | |||||||||||||
| time | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | 17 (15, 19) | ||||||||||||||
| n | 32 (18, 47) | 2 (2, 3) | 4 (3, 4) | 5 (4, 6) | ||||||||||||||
| post_p | 0.34 (0.27, 0.41) | 0.21 (0.16, 0.26) | 0.3 (0.2, 0.39) | 0.4 (0.39, 0.4) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.138 (0.121, 0.155) | 0.573 (0.374, 0.773) | 0.231 (0.144, 0.318) | 0.118 (0.084, 0.153) | ||||||||||||||
| Taxel_therapies | count | 185 | 185 | 185 | 185 | |||||||||||||
| time | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | ||||||||||||||
| n | 21 (10, 60) | 6 (3, 13) | 4 (1, 10) | 4 (1, 9) | ||||||||||||||
| post_p | 0.34 (0.1, 0.47) | 0.34 (0.15, 0.47) | 0.32 (0.16, 0.47) | 0.32 (0.15, 0.47) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.128 (0.106, 0.193) | 0.155 (0.107, 0.345) | 0.151 (0.083, 0.55) | 0.142 (0.085, 0.428) | ||||||||||||||
| TP53+ | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||
| n | 12 (12, 12) | 5 (5, 5) | 0 (0, 0) | 2 (2, 2) | 1 (1, 1) | 1 (1, 1) | 3 (3, 3) | 2 (2, 2) | ||||||||||
| post_p | 0.36 (0.36, 0.36) | 0.47 (0.47, 0.47) | NA (NA, NA) | 0.38 (0.38, 0.38) | 0.34 (0.34, 0.34) | 0.34 (0.34, 0.34) | 0.5 (0.5, 0.5) | 0.36 (0.36, 0.36) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.17 (0.17, 0.17) | 0.092 (0.092, 0.092) | NA (NA, NA) | 0.165 (0.165, 0.165) | 0.301 (0.301, 0.301) | 0.565 (0.565, 0.565) | 0.078 (0.078, 0.078) | 0.592 (0.592, 0.592) | ||||||||||
| Hormone_therapies | count | 63 | 63 | 63 | 63 | 63 | 63 | 63 | 63 | |||||||||
| time | 23 (11, 33) | 23 (11, 33) | 23 (11, 33) | 23 (11, 33) | 23 (11, 33) | 23 (11, 33) | 23 (11, 33) | 23 (11, 33) | ||||||||||
| n | 14 (8, 32) | 8 (3, 22) | 2 (1, 5) | 2 (0, 7) | 4 (1, 10) | 3 (1, 7) | 2 (0, 6) | 2 (1, 6) | ||||||||||
| post_p | 0.3 (0.12, 0.47) | 0.36 (0.12, 0.48) | 0.35 (0.2, 0.47) | 0.36 (0.21, 0.47) | 0.36 (0.22, 0.47) | 0.36 (0.22, 0.48) | 0.37 (0.2, 0.45) | 0.34 (0.17, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.142 (0.111, 0.217) | 0.139 (0.097, 0.316) | 0.172 (0.066, 0.67) | 0.153 (0.082, 0.595) | 0.171 (0.097, 0.83) | 0.176 (0.1, 0.546) | 0.175 (0.075, 0.397) | 0.181 (0.09, 0.828) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 6 (6, 6) | 2 (2, 2) | 4 (4, 4) | 3 (3, 3) | 3 (3, 3) | 1 (1, 1) | 3 (3, 3) | 3 (3, 3) | ||||||||||
| post_p | 0.21 (0.21, 0.21) | 0.28 (0.28, 0.28) | 0.44 (0.44, 0.44) | 0.33 (0.33, 0.33) | 0.4 (0.4, 0.4) | 0.21 (0.21, 0.21) | 0.48 (0.48, 0.48) | 0.46 (0.46, 0.46) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.195 (0.195, 0.195) | 0.365 (0.365, 0.365) | 0.077 (0.077, 0.077) | 0.139 (0.139, 0.139) | 0.277 (0.277, 0.277) | 0.36 (0.36, 0.36) | 0 (0, 0) | 0.086 (0.086, 0.086) | ||||||||||
| Taxel_therapies | count | 63 | 63 | 63 | 63 | 63 | 63 | 63 | 63 | |||||||||
| time | 19 (10, 32) | 19 (10, 32) | 19 (10, 32) | 19 (10, 32) | 19 (10, 32) | 19 (10, 32) | 19 (10, 32) | 19 (10, 32) | ||||||||||
| n | 9 (5, 25) | 11 (5, 19) | 2 (0, 4) | 2 (0, 5) | 4 (2, 9) | 4 (1, 9) | 2 (0, 6) | 2 (0, 5) | ||||||||||
| post_p | 0.28 (0.16, 0.45) | 0.37 (0.17, 0.48) | 0.36 (0.22, 0.47) | 0.33 (0.15, 0.48) | 0.36 (0.17, 0.46) | 0.35 (0.19, 0.45) | 0.35 (0.22, 0.48) | 0.39 (0.2, 0.5) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.146 (0.103, 0.254) | 0.143 (0.103, 0.241) | 0.162 (0.069, 0.646) | 0.171 (0.078, 0.503) | 0.162 (0.11, 0.422) | 0.177 (0.102, 0.42) | 0.159 (0.069, 0.531) | 0.141 (0.062, 0.552) |