Simulation scenario 6

Setting description

Carboplatin more effective in the DRD+ biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 10 1 16 10 TP53- & AR- 30 31 123 133 TP53+ 5 2 24 27 DRD+ 0 1 267 280 TEfus+ 2 4 31 41

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.020 0.002 0.032 0.020 TP53- & AR- 0.060 0.062 0.246 0.266 TP53+ 0.010 0.004 0.048 0.054 DRD+ 0.000 0.002 0.534 0.560 TEfus+ 0.004 0.008 0.062 0.082

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 17 2 0 0 TP53- & AR- 220 185 8 2 TP53+ 63 63 1 1 DRD+ 78 92 0 0 TEfus+ 59 68 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.034 0.004 0.000 0.000 TP53- & AR- 0.440 0.370 0.016 0.004 TP53+ 0.126 0.126 0.002 0.002 DRD+ 0.156 0.184 0.000 0.000 TEfus+ 0.118 0.136 0.000 0.000

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 18 15 11 13 TP53+ 6 14 8 8 DRD+ 0 0 0 0 TEfus+ 0 0 0 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.036 0.030 0.022 0.026 TP53+ 0.012 0.028 0.016 0.016 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.004

Errors & power

The overall error was 0.372.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.094             0.076             0.136             0.130 

The overall power was 0.786.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.534             0.560 

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	16	0	10	10	1
	futility	0	0	17	0	2
	max_n	0	0	0	0	0
	n	184 (109, 254)	430 (397, 463)	176 (109, 252)	184 (117, 256)	181 (121, 262)
	n_unique	170 (98, 239)	394 (364, 424)	162 (100, 235)	169 (107, 238)	169 (110, 247)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	7 (6, 24)	NA (NA, NA)	5 (4, 33)	10 (7, 29)	21 (7, 23)
	post_p	1 (1, 1)	NA (NA, NA)	0.41 (0.06, 0.84)	1 (1, 1)	0.46 (0.08, 0.85)
	rate	0.072 (0.062, 0.084)	0.112 (0.105, 0.12)	0.114 (0.103, 0.129)	0.072 (0.062, 0.085)	0.112 (0.102, 0.126)
DRD+	graduation	267	0	0	280	1
	futility	0	0	78	0	92
	max_n	0	0	0	0	0
	n	67 (27, 102)	118 (101, 135)	34 (19, 63)	65 (27, 103)	36 (24, 63)
	n_unique	62 (25, 95)	107 (90, 123)	30 (17, 56)	60 (25, 96)	32 (22, 57)
	time_trial	34 (12, 36)	36 (36, 36)	36 (31, 36)	32 (12, 36)	36 (28, 36)
	time_stop	19 (11, 32)	NA (NA, NA)	29 (22, 35)	18 (10, 32)	28 (21, 33)
	post_p	1 (1, 1)	NA (NA, NA)	0.36 (0.07, 0.77)	1 (1, 1)	0.36 (0.08, 0.8)
	rate	0.036 (0.029, 0.045)	0.112 (0.098, 0.126)	0.115 (0.092, 0.152)	0.036 (0.028, 0.044)	0.114 (0.09, 0.145)
TEfus+	graduation	31	0	2	41	4
	futility	0	0	59	0	68
	max_n	0	0	0	2	0
	n	70 (37, 105)	157 (139, 177)	63 (31, 91)	68 (40, 103)	72 (40, 101)
	n_unique	64 (34, 98)	143 (126, 161)	57 (29, 84)	63 (37, 95)	67 (37, 92)
	time_trial	36 (36, 36)	36 (36, 36)	36 (30, 36)	36 (36, 36)	36 (27, 36)
	time_stop	14 (11, 20)	NA (NA, NA)	23 (16, 32)	15 (11, 28)	23 (10, 32)
	post_p	1 (0.94, 1)	NA (NA, NA)	0.4 (0.07, 0.82)	1 (0.95, 1)	0.39 (0.07, 0.8)
	rate	0.064 (0.051, 0.082)	0.112 (0.1, 0.125)	0.114 (0.095, 0.144)	0.065 (0.049, 0.079)	0.115 (0.097, 0.136)
TP53- & AR-	graduation	123	0	30	133	31
	futility	8	0	220	2	185
	max_n	11	0	18	13	15
	n	62 (27, 124)	180 (155, 205)	58 (26, 133)	65 (28, 125)	64 (26, 128)
	n_unique	57 (25, 116)	166 (142, 188)	55 (25, 126)	59 (26, 117)	59 (24, 121)
	time_trial	36 (14, 36)	36 (36, 36)	36 (10, 36)	36 (15, 36)	36 (16, 36)
	time_stop	16 (10, 30)	NA (NA, NA)	16 (7, 29)	18 (10, 31)	20 (12, 32)
	post_p	0.99 (0.81, 1)	NA (NA, NA)	0.41 (0.06, 0.83)	0.99 (0.82, 1)	0.42 (0.08, 0.87)
	rate	0.072 (0.053, 0.093)	0.112 (0.101, 0.126)	0.117 (0.097, 0.146)	0.074 (0.052, 0.095)	0.114 (0.097, 0.149)
TP53+	graduation	24	0	5	27	2
	futility	1	0	63	1	63
	max_n	8	0	6	8	14
	n	86 (47, 125)	190 (167, 211)	82 (37, 124)	83 (47, 124)	86 (46, 126)
	n_unique	78 (42, 119)	172 (152, 193)	76 (34, 115)	78 (42, 114)	79 (40, 118)
	time_trial	36 (36, 36)	36 (36, 36)	36 (29, 36)	36 (36, 36)	36 (26, 36)
	time_stop	13 (9, 22)	NA (NA, NA)	22 (9, 32)	16 (10, 32)	19 (10, 32)
	post_p	0.99 (0.84, 1)	NA (NA, NA)	0.4 (0.06, 0.84)	0.99 (0.84, 1)	0.4 (0.07, 0.87)
	rate	0.075 (0.06, 0.093)	0.112 (0.101, 0.124)	0.113 (0.099, 0.141)	0.075 (0.059, 0.093)	0.114 (0.097, 0.138)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	144	0	273	142	217
	futility	0	0	0	0	0
	max_n	11	0	18	13	15
	n	27 (9, 84)	114 (93, 135)	35 (16, 102)	29 (10, 89)	36 (12, 95)
	n_unique	25 (8, 80)	106 (86, 126)	33 (16, 98)	26 (8, 84)	34 (10, 90)
	post_p	0.46 (0.1, 0.89)	NA (NA, NA)	0.44 (0.1, 0.87)	0.48 (0.08, 0.88)	0.46 (0.1, 0.87)
	rate	0.117 (0.09, 0.186)	0.113 (0.099, 0.131)	0.118 (0.097, 0.159)	0.115 (0.092, 0.179)	0.116 (0.095, 0.175)
—+	graduation	167	0	294	167	248
	futility	0	0	0	0	0
	max_n	11	0	18	14	14
	n	6 (2, 17)	22 (15, 30)	7 (2, 20)	6 (2, 18)	8 (3, 22)
	n_unique	5 (1, 17)	20 (14, 27)	6 (2, 19)	5 (1, 16)	8 (3, 20)
	post_p	0.47 (0.18, 0.82)	NA (NA, NA)	0.43 (0.18, 0.81)	0.44 (0.18, 0.81)	0.44 (0.16, 0.85)
	rate	0.12 (0.072, 0.279)	0.113 (0.081, 0.156)	0.128 (0.08, 0.289)	0.125 (0.071, 0.326)	0.125 (0.081, 0.272)
–+-	graduation	39	0	90	37	66
	futility	0	0	0	0	0
	max_n	8	0	6	8	14
	n	22 (6, 50)	63 (50, 77)	28 (8, 60)	23 (6, 53)	24 (7, 55)
	n_unique	20 (5, 47)	57 (45, 72)	26 (8, 56)	21 (6, 49)	22 (6, 52)
	post_p	0.44 (0.12, 0.87)	NA (NA, NA)	0.45 (0.11, 0.87)	0.45 (0.1, 0.88)	0.41 (0.1, 0.86)
	rate	0.118 (0.09, 0.21)	0.113 (0.093, 0.138)	0.119 (0.092, 0.181)	0.118 (0.089, 0.218)	0.121 (0.091, 0.206)
–++	graduation	63	0	127	66	121
	futility	0	0	0	0	0
	max_n	8	0	6	10	13
	n	15 (4, 35)	42 (33, 53)	16 (4, 37)	13 (4, 33)	21 (7, 43)
	n_unique	14 (3, 33)	39 (30, 49)	15 (4, 35)	12 (3, 31)	19 (6, 40)
	post_p	0.5 (0.15, 0.85)	NA (NA, NA)	0.43 (0.13, 0.84)	0.44 (0.13, 0.84)	0.45 (0.11, 0.87)
	rate	0.115 (0.085, 0.226)	0.112 (0.089, 0.143)	0.121 (0.088, 0.261)	0.124 (0.085, 0.252)	0.119 (0.09, 0.22)
-+–	graduation	332	0	313	333	264
	futility	0	0	0	0	0
	max_n	10	0	18	12	15
	n	10 (3, 22)	21 (14, 29)	4 (0, 13)	10 (3, 22)	5 (2, 14)
	n_unique	9 (3, 21)	19 (13, 26)	4 (0, 12)	9 (3, 21)	5 (2, 13)
	post_p	0.96 (0.63, 1)	NA (NA, NA)	0.36 (0.14, 0.66)	0.95 (0.7, 1)	0.34 (0.15, 0.66)
	rate	0.037 (0.02, 0.07)	0.114 (0.084, 0.151)	0.126 (0.072, 0.406)	0.038 (0.021, 0.067)	0.125 (0.071, 0.34)
-+-+	graduation	337	0	328	338	288
	futility	0	0	0	0	0
	max_n	10	0	18	13	14
	n	10 (3, 23)	21 (15, 28)	4 (0, 13)	10 (3, 23)	5 (1, 14)
	n_unique	9 (3, 22)	19 (13, 26)	3 (0, 12)	9 (3, 21)	4 (1, 13)
	post_p	0.95 (0.69, 1)	NA (NA, NA)	0.35 (0.17, 0.65)	0.96 (0.72, 1)	0.32 (0.13, 0.67)
	rate	0.036 (0.018, 0.066)	0.112 (0.083, 0.151)	0.133 (0.073, 0.405)	0.036 (0.019, 0.066)	0.128 (0.072, 0.365)
-++-	graduation	282	0	152	293	149
	futility	0	0	0	0	0
	max_n	7	0	6	7	13
	n	6 (2, 14)	12 (8, 18)	3 (1, 9)	6 (2, 13)	4 (1, 9)
	n_unique	6 (1, 13)	11 (7, 17)	3 (0, 8)	5 (1, 12)	3 (1, 8)
	post_p	0.87 (0.5, 0.99)	NA (NA, NA)	0.34 (0.16, 0.65)	0.86 (0.5, 0.99)	0.36 (0.18, 0.63)
	rate	0.038 (0.016, 0.095)	0.114 (0.074, 0.175)	0.139 (0.068, 0.51)	0.036 (0.015, 0.1)	0.133 (0.065, 0.474)
-+++	graduation	287	0	183	299	190
	futility	0	0	0	0	0
	max_n	7	0	6	9	13
	n	6 (1, 14)	12 (8, 18)	4 (1, 10)	6 (2, 14)	4 (1, 9)
	n_unique	6 (1, 13)	11 (7, 16)	3 (1, 9)	5 (1, 13)	3 (1, 8)
	post_p	0.88 (0.49, 0.99)	NA (NA, NA)	0.36 (0.18, 0.65)	0.86 (0.49, 0.99)	0.36 (0.17, 0.65)
	rate	0.038 (0.013, 0.099)	0.113 (0.076, 0.171)	0.131 (0.068, 0.426)	0.038 (0.013, 0.094)	0.133 (0.064, 0.351)
+—	graduation	16	0	27	10	3
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (2, 18)	20 (14, 27)	8 (2, 18)	8 (3, 17)	11 (4, 21)
	n_unique	7 (2, 16)	18 (13, 24)	7 (2, 17)	7 (2, 15)	10 (4, 20)
	post_p	0.47 (0.19, 0.85)	NA (NA, NA)	0.42 (0.18, 0.84)	0.46 (0.18, 0.85)	0.49 (0.16, 0.81)
	rate	0.124 (0.073, 0.294)	0.117 (0.085, 0.16)	0.129 (0.078, 0.316)	0.124 (0.072, 0.349)	0.121 (0.082, 0.258)
+–+	graduation	46	0	84	46	73
	futility	0	0	0	0	0
	max_n	0	0	0	2	0
	n	6 (2, 13)	16 (11, 22)	7 (2, 16)	6 (2, 14)	8 (3, 18)
	n_unique	5 (1, 12)	15 (10, 21)	6 (2, 15)	5 (2, 13)	8 (3, 16)
	post_p	0.45 (0.2, 0.84)	NA (NA, NA)	0.43 (0.18, 0.83)	0.48 (0.2, 0.81)	0.44 (0.17, 0.86)
	rate	0.131 (0.071, 0.428)	0.116 (0.079, 0.166)	0.132 (0.075, 0.406)	0.125 (0.068, 0.37)	0.127 (0.073, 0.268)
+-+-	graduation	39	0	90	37	66
	futility	0	0	0	0	0
	max_n	8	0	6	8	14
	n	6 (2, 15)	16 (11, 22)	6 (1, 15)	6 (2, 14)	8 (2, 16)
	n_unique	5 (1, 13)	15 (10, 20)	6 (1, 14)	5 (2, 13)	7 (2, 15)
	post_p	0.46 (0.2, 0.82)	NA (NA, NA)	0.44 (0.2, 0.84)	0.45 (0.19, 0.82)	0.46 (0.18, 0.83)
	rate	0.125 (0.071, 0.388)	0.114 (0.08, 0.167)	0.128 (0.072, 0.361)	0.125 (0.073, 0.371)	0.123 (0.074, 0.328)
+-++	graduation	63	0	127	66	121
	futility	0	0	0	0	0
	max_n	8	0	6	10	13
	n	6 (2, 14)	17 (11, 22)	6 (2, 15)	6 (2, 14)	8 (3, 17)
	n_unique	5 (1, 13)	15 (10, 20)	5 (2, 14)	6 (2, 13)	8 (2, 16)
	post_p	0.45 (0.2, 0.81)	NA (NA, NA)	0.42 (0.19, 0.83)	0.49 (0.22, 0.84)	0.47 (0.19, 0.84)
	rate	0.13 (0.075, 0.321)	0.113 (0.079, 0.167)	0.134 (0.072, 0.354)	0.118 (0.071, 0.337)	0.122 (0.079, 0.311)
++–	graduation	278	0	102	285	95
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 14)	12 (8, 17)	3 (1, 9)	6 (2, 14)	3 (1, 9)
	n_unique	6 (2, 13)	11 (7, 16)	3 (1, 8)	5 (2, 13)	3 (1, 8)
	post_p	0.88 (0.51, 0.99)	NA (NA, NA)	0.36 (0.17, 0.66)	0.87 (0.48, 0.99)	0.36 (0.19, 0.68)
	rate	0.037 (0.014, 0.095)	0.115 (0.075, 0.178)	0.132 (0.062, 0.439)	0.037 (0.014, 0.1)	0.13 (0.063, 0.445)
++-+	graduation	284	0	148	292	149
	futility	0	0	0	0	0
	max_n	0	0	0	2	0
	n	6 (2, 14)	12 (8, 17)	4 (1, 9)	6 (2, 14)	4 (1, 8)
	n_unique	5 (2, 13)	11 (7, 16)	3 (1, 8)	6 (1, 13)	3 (1, 8)
	post_p	0.86 (0.51, 0.98)	NA (NA, NA)	0.35 (0.16, 0.67)	0.89 (0.57, 0.98)	0.35 (0.18, 0.64)
	rate	0.037 (0.015, 0.093)	0.112 (0.073, 0.171)	0.131 (0.061, 0.39)	0.036 (0.014, 0.08)	0.136 (0.063, 0.397)
+++-	graduation	282	0	152	293	149
	futility	0	0	0	0	0
	max_n	7	0	6	7	13
	n	6 (2, 14)	12 (8, 17)	3 (1, 9)	6 (2, 14)	4 (1, 9)
	n_unique	6 (1, 13)	11 (7, 16)	3 (1, 9)	5 (1, 13)	3 (1, 8)
	post_p	0.85 (0.54, 0.98)	NA (NA, NA)	0.36 (0.16, 0.65)	0.87 (0.52, 0.99)	0.36 (0.18, 0.65)
	rate	0.038 (0.017, 0.085)	0.112 (0.074, 0.179)	0.129 (0.059, 0.333)	0.035 (0.014, 0.087)	0.129 (0.062, 0.392)
++++	graduation	287	0	183	299	190
	futility	0	0	0	0	0
	max_n	7	0	6	9	13
	n	5 (2, 13)	12 (8, 18)	4 (1, 9)	6 (2, 14)	3 (1, 9)
	n_unique	5 (1, 13)	11 (7, 16)	3 (1, 8)	5 (1, 13)	3 (1, 9)
	post_p	0.86 (0.49, 0.98)	NA (NA, NA)	0.38 (0.18, 0.69)	0.88 (0.47, 0.98)	0.36 (0.17, 0.64)
	rate	0.038 (0.015, 0.097)	0.11 (0.071, 0.177)	0.122 (0.057, 0.386)	0.037 (0.015, 0.092)	0.132 (0.061, 0.431)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	10	1	16	10
	time_stop	5 (4, 6)	4 (4, 4)	7 (6, 24)	10 (7, 29)
	n_trt	31 (29, 41)	25 (25, 25)	36 (28, 130)	50 (36, 118)
	n_control	56 (51, 70)	43 (43, 43)	76 (60, 300)	108 (78, 348)
	post_p	0.89 (0.86, 0.93)	0.88 (0.88, 0.88)	1 (0.97, 1)	1 (0.98, 1)
	order	1 (1, 1)	1 (1, 1)	1 (1, 3.5)	1 (1, 6)
TP53- & AR-	count	30	31	123	133
	time_stop	9 (6, 15)	15 (11, 23)	15 (10, 30)	18 (10, 31)
	n_trt	30 (26, 46)	36 (27, 56)	33 (26, 77)	41 (25, 93)
	n_control	43 (27, 67)	63 (51, 111)	69 (41, 149)	79 (46, 148)
	post_p	0.9 (0.86, 0.96)	0.92 (0.88, 0.96)	0.98 (0.91, 1)	0.99 (0.92, 1)
	order	1 (1, 1.1)	1 (1, 3)	2 (1, 3)	2 (1, 3)
TP53+	count	5	2	24	27
	time_stop	9 (8, 10)	8 (7, 10)	13 (9, 22)	16 (10, 32)
	n_trt	29 (26, 30)	26 (25, 28)	33 (26, 60)	39 (27, 103)
	n_control	38 (33, 44)	46 (38, 54)	64 (41, 109)	73 (41, 176)
	post_p	0.95 (0.92, 0.97)	0.9 (0.9, 0.9)	1 (0.94, 1)	1 (0.94, 1)
	order	1 (1, 1)	1.5 (1.1, 1.9)	2 (1, 3.7)	2 (1, 3.4)
DRD+	count		1	267	280
	time_stop		21 (21, 21)	19 (11, 32)	18 (10, 32)
	n_trt		25 (25, 25)	41 (26, 83)	42 (26, 86)
	n_control		69 (69, 69)	57 (28, 100)	50 (27, 108)
	post_p		0.98 (0.98, 0.98)	1 (0.98, 1)	1 (0.98, 1)
	order		1 (1, 1)	2 (1, 4)	2 (1, 3)
TEfus+	count	2	4	31	41
	time_stop	12 (11, 13)	10 (9, 11)	14 (11, 20)	15 (11, 28)
	n_trt	30 (28, 32)	28 (25, 31)	28 (25, 42)	29 (25, 67)
	n_control	50 (45, 54)	32 (31, 42)	51 (42, 79)	57 (40, 103)
	post_p	0.96 (0.94, 0.97)	0.94 (0.88, 0.95)	1 (0.95, 1)	1 (0.97, 1)
	order	1.5 (1.1, 1.9)	1 (1, 1)	2 (1, 3)	2 (1, 4)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	17	2
	time_stop	5 (4, 35)	22 (21, 24)
	n_trt	31 (25, 135)	98 (80, 116)
	n_control	50 (37, 411)	258 (244, 271)
	post_p	0.08 (0, 0.18)	0.01 (0.01, 0.02)
	order	1 (1, 4.4)	4.5 (4.1, 4.9)
TP53- & AR-	count	220	185	8	2
	time_stop	16 (8, 30)	21 (13, 32)	17 (15, 24)	17 (15, 19)
	n_trt	38 (26, 74)	35 (25, 80)	34 (28, 66)	44 (29, 58)
	n_control	74 (32, 148)	101 (55, 162)	71 (60, 140)	89 (75, 103)
	post_p	0.15 (0.05, 0.27)	0.16 (0.05, 0.27)	0.17 (0.12, 0.27)	0.16 (0.13, 0.19)
	order	1 (1, 2)	2 (1, 3)	2 (1, 3.3)	2 (1.2, 2.8)
TP53+	count	63	63	1	1
	time_stop	23 (11, 33)	19 (10, 32)	11 (11, 11)	10 (10, 10)
	n_trt	41 (26, 77)	38 (26, 68)	26 (26, 26)	25 (25, 25)
	n_control	113 (46, 178)	88 (38, 174)	40 (40, 40)	39 (39, 39)
	post_p	0.08 (0.01, 0.24)	0.08 (0.01, 0.22)	0.13 (0.13, 0.13)	0.09 (0.09, 0.09)
	order	2 (1, 4)	1 (1, 3)	1 (1, 1)	1 (1, 1)
DRD+	count	78	92
	time_stop	29 (22, 35)	28 (21, 33)
	n_trt	31 (25, 47)	29 (25, 50)
	n_control	91 (66, 112)	90 (59, 117)
	post_p	0.08 (0.02, 0.24)	0.1 (0.02, 0.22)
	order	2 (1, 4)	2 (1, 4)
TEfus+	count	59	68
	time_stop	23 (16, 32)	23 (13, 32)
	n_trt	35 (26, 55)	40 (27, 64)
	n_control	94 (60, 142)	91 (46, 140)
	post_p	0.07 (0.01, 0.19)	0.06 (0.02, 0.21)
	order	2 (1, 4)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16
		time	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)	7 (6, 24)
		n	8 (2, 26)	2 (0, 6)	6 (3, 20)	3 (0, 14)	4 (0, 8)	3 (1, 6)	2 (0, 4)	1 (0, 4)	0 (0, 7)	2 (0, 6)	1 (0, 5)	1 (0, 7)	2 (0, 6)	3 (1, 6)	2 (1, 6)	2 (0, 4)
		post_p	0.71 (0.6, 0.8)	0.64 (0.55, 0.71)	0.63 (0.53, 0.7)	0.59 (0.56, 0.7)	0.58 (0.5, 0.76)	0.64 (0.54, 0.8)	0.58 (0.53, 0.8)	0.58 (0.52, 0.71)	0.54 (0.51, 0.7)	0.59 (0.54, 0.74)	0.56 (0.51, 0.65)	0.61 (0.51, 0.74)	0.73 (0.55, 0.93)	0.61 (0.53, 0.82)	0.67 (0.53, 0.87)	0.63 (0.51, 0.71)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.036 (0, 0.094)	0 (0, 0.093)	0.074 (0, 0.099)	0.017 (0, 0.121)	0 (0, 0.049)	0 (0, 0.074)	0 (0, 0.04)	0 (0, 0.039)	0 (0, 0.119)	0 (0, 0.095)	0 (0, 0.091)	0 (0, 0.097)	0 (0, 0.028)	0 (0, 0.044)	0 (0, 0.042)	0 (0, 0.075)
	Hormone_therapies	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
		time	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)	5 (4, 6)
		n	15 (13, 16)	2 (1, 5)	8 (6, 10)	4 (1, 7)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 2)	0 (0, 3)	2 (0, 3)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
		post_p	0.74 (0.64, 0.93)	0.6 (0.52, 0.65)	0.68 (0.6, 0.78)	0.7 (0.54, 0.75)	NA (NA, NA)	0.53 (0.51, 0.59)	0.51 (0.51, 0.51)	0.54 (0.53, 0.55)	0.65 (0.57, 0.7)	0.64 (0.52, 0.74)	0.56 (0.55, 0.6)	0.57 (0.53, 0.6)	NA (NA, NA)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	0.51 (0.5, 0.53)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.045 (0.023, 0.073)	0.043 (0, 0.204)	0.039 (0, 0.08)	0 (0, 0.113)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.125)	0 (0, 0)	0 (0, 0.099)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Niraparib	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
		time	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)	10 (7, 29)
		n	11 (4, 31)	2 (0, 4)	8 (5, 24)	4 (2, 13)	3 (0, 8)	6 (5, 7)	2 (1, 6)	3 (1, 4)	2 (0, 13)	0 (0, 4)	1 (1, 6)	2 (0, 3)	2 (1, 4)	3 (1, 5)	3 (2, 4)	2 (0, 4)
		post_p	0.65 (0.5, 0.84)	0.7 (0.54, 0.81)	0.6 (0.55, 0.88)	0.68 (0.61, 0.86)	0.7 (0.56, 0.95)	0.73 (0.61, 0.96)	0.67 (0.6, 0.8)	0.64 (0.53, 0.77)	0.58 (0.51, 0.75)	0.57 (0.55, 0.6)	0.56 (0.5, 0.69)	0.56 (0.52, 0.8)	0.76 (0.56, 0.96)	0.61 (0.52, 0.89)	0.69 (0.59, 0.81)	0.7 (0.51, 0.89)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.09 (0.028, 0.116)	0.059 (0, 0.08)	0.097 (0, 0.127)	0.027 (0, 0.069)	0.025 (0, 0.033)	0.032 (0, 0.066)	0 (0, 0.053)	0.039 (0, 0.089)	0.046 (0, 0.099)	0.072 (0.026, 0.091)	0 (0, 0.134)	0 (0, 0.108)	0 (0, 0.022)	0.004 (0, 0.11)	0.025 (0, 0.069)	0 (0, 0.025)
	Taxel_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	5 (5, 5)	0 (0, 0)	7 (7, 7)	4 (4, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 0)	2 (2, 2)	5 (5, 5)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.76 (0.76, 0.76)	NA (NA, NA)	0.53 (0.53, 0.53)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.76 (0.76, 0.76)	NA (NA, NA)	0.51 (0.51, 0.51)	0.58 (0.58, 0.58)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.12 (0.12, 0.12)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0.069 (0.069, 0.069)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
DRD+	Carboplatin	count					267	267	267	267					267	267	267	267
		time					19 (11, 32)	19 (11, 32)	19 (11, 32)	19 (11, 32)					19 (11, 32)	19 (11, 32)	19 (11, 32)	19 (11, 32)
		n					7 (3, 17)	8 (3, 16)	5 (2, 11)	5 (1, 11)					4 (1, 10)	4 (2, 11)	4 (1, 11)	4 (1, 11)
		post_p					0.81 (0.6, 0.97)	0.81 (0.62, 0.97)	0.74 (0.56, 0.95)	0.74 (0.53, 0.94)					0.74 (0.54, 0.93)	0.75 (0.54, 0.94)	0.74 (0.55, 0.93)	0.74 (0.54, 0.95)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.035 (0, 0.064)	0.033 (0, 0.064)	0.028 (0, 0.068)	0.03 (0, 0.071)					0.029 (0, 0.074)	0.029 (0, 0.077)	0.031 (0, 0.068)	0.028 (0, 0.068)
	Niraparib	count					280	280	280	280					280	280	280	280
		time					18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)					18 (10, 32)	18 (10, 32)	18 (10, 32)	18 (10, 32)
		n					7 (3, 16)	8 (3, 17)	4 (1, 11)	4 (1, 10)					4 (1, 11)	4 (1, 11)	4 (2, 11)	4 (1, 11)
		post_p					0.8 (0.59, 0.98)	0.82 (0.62, 0.98)	0.74 (0.54, 0.93)	0.72 (0.54, 0.93)					0.74 (0.54, 0.93)	0.76 (0.56, 0.94)	0.72 (0.53, 0.92)	0.75 (0.54, 0.95)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.032 (0, 0.07)	0.029 (0, 0.06)	0.028 (0, 0.071)	0.03 (0, 0.072)					0.028 (0, 0.07)	0.027 (0, 0.068)	0.029 (0, 0.072)	0.026 (0, 0.068)
	Taxel_therapies	count					1	1	1	1					1	1	1	1
		time					21 (21, 21)	21 (21, 21)	21 (21, 21)	21 (21, 21)					21 (21, 21)	21 (21, 21)	21 (21, 21)	21 (21, 21)
		n					4 (4, 4)	4 (4, 4)	4 (4, 4)	0 (0, 0)					1 (1, 1)	5 (5, 5)	3 (3, 3)	4 (4, 4)
		post_p					0.67 (0.67, 0.67)	0.54 (0.54, 0.54)	0.5 (0.5, 0.5)	NA (NA, NA)					0.5 (0.5, 0.5)	0.84 (0.84, 0.84)	0.87 (0.87, 0.87)	0.5 (0.5, 0.5)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.06 (0.06, 0.06)	0.114 (0.114, 0.114)	0.081 (0.081, 0.081)	NA (NA, NA)					0 (0, 0)	0.039 (0.039, 0.039)	0 (0, 0)	0.07 (0.07, 0.07)
TEfus+	Carboplatin	count		31		31		31		31		31		31		31		31
		time		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)		14 (11, 20)
		n		3 (1, 5)		6 (3, 14)		5 (4, 8)		3 (2, 6)		2 (1, 5)		3 (1, 7)		3 (1, 5)		4 (1, 5)
		post_p		0.61 (0.51, 0.73)		0.73 (0.53, 0.8)		0.77 (0.61, 0.92)		0.73 (0.55, 0.91)		0.61 (0.53, 0.85)		0.68 (0.54, 0.8)		0.68 (0.58, 0.82)		0.7 (0.53, 0.85)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.071 (0, 0.127)		0.075 (0.04, 0.1)		0.03 (0, 0.061)		0 (0, 0.064)		0.036 (0, 0.115)		0.045 (0, 0.117)		0.031 (0, 0.087)		0.008 (0, 0.076)
	Hormone_therapies	count		2		2		2		2		2		2		2		2
		time		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)
		n		6 (3, 8)		14 (10, 18)		1 (0, 2)		2 (0, 3)		2 (1, 4)		3 (2, 4)		2 (1, 2)		2 (0, 3)
		post_p		0.75 (0.69, 0.81)		0.87 (0.83, 0.91)		0.69 (0.69, 0.69)		0.5 (0.5, 0.5)		0.66 (0.61, 0.71)		0.52 (0.51, 0.52)		0.54 (0.54, 0.54)		0.59 (0.59, 0.59)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.017 (0.003, 0.031)		0.055 (0.05, 0.061)		0 (0, 0)		0 (0, 0)		0.031 (0.006, 0.056)		0.025 (0.005, 0.045)		0 (0, 0)		0 (0, 0)
	Niraparib	count		41		41		41		41		41		41		41		41
		time		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)		15 (11, 28)
		n		3 (1, 7)		7 (3, 18)		7 (4, 12)		3 (2, 7)		3 (1, 7)		3 (0, 7)		4 (1, 8)		3 (1, 8)
		post_p		0.64 (0.53, 0.84)		0.75 (0.6, 0.86)		0.83 (0.72, 0.94)		0.72 (0.54, 0.89)		0.6 (0.52, 0.84)		0.67 (0.55, 0.81)		0.71 (0.52, 0.88)		0.7 (0.55, 0.92)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.059 (0, 0.098)		0.066 (0, 0.097)		0.019 (0, 0.054)		0.023 (0, 0.069)		0.033 (0, 0.12)		0.065 (0, 0.113)		0.029 (0, 0.086)		0.014 (0, 0.07)
	Taxel_therapies	count		4		4		4		4		4		4		4		4
		time		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)		10 (9, 11)
		n		4 (4, 5)		8 (6, 13)		1 (0, 3)		1 (0, 2)		4 (3, 6)		3 (3, 4)		2 (1, 4)		2 (1, 2)
		post_p		0.68 (0.65, 0.74)		0.81 (0.66, 0.95)		0.58 (0.52, 0.72)		0.52 (0.52, 0.53)		0.7 (0.56, 0.94)		0.7 (0.64, 0.75)		0.54 (0.51, 0.64)		0.53 (0.52, 0.61)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.054 (0.048, 0.096)		0.085 (0.063, 0.088)		0 (0, 0)		0 (0, 0)		0.043 (0, 0.086)		0.1 (0.067, 0.145)		0 (0, 0)		0 (0, 0)
TP53- & AR-	Carboplatin	count	123	123			123	123
		time	15 (10, 30)	15 (10, 30)			15 (10, 30)	15 (10, 30)
		n	19 (12, 48)	3 (1, 8)			6 (3, 15)	6 (3, 15)
		post_p	0.78 (0.71, 0.91)	0.61 (0.51, 0.79)			0.79 (0.54, 0.98)	0.78 (0.56, 0.98)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.076 (0.04, 0.103)	0.068 (0, 0.114)			0.031 (0, 0.071)	0.03 (0, 0.066)
	Hormone_therapies	count	30	30			30	30
		time	9 (6, 15)	9 (6, 15)			9 (6, 15)	9 (6, 15)
		n	24 (20, 34)	3 (2, 8)			1 (0, 5)	1 (0, 3)
		post_p	0.89 (0.76, 0.96)	0.63 (0.52, 0.85)			0.62 (0.5, 0.74)	0.55 (0.51, 0.68)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.067 (0.035, 0.102)	0.056 (0, 0.121)			0 (0, 0.07)	0 (0, 0.071)
	Niraparib	count	133	133			133	133
		time	18 (10, 31)	18 (10, 31)			18 (10, 31)	18 (10, 31)
		n	20 (12, 61)	4 (1, 12)			6 (3, 14)	8 (3, 14)
		post_p	0.76 (0.71, 0.93)	0.64 (0.51, 0.81)			0.87 (0.62, 0.98)	0.82 (0.67, 0.97)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.079 (0.047, 0.104)	0.074 (0, 0.126)			0.032 (0, 0.06)	0.031 (0, 0.06)
	Taxel_therapies	count	31	31			31	31
		time	15 (11, 23)	15 (11, 23)			15 (11, 23)	15 (11, 23)
		n	27 (16, 36)	5 (2, 13)			3 (0, 5)	2 (0, 5)
		post_p	0.79 (0.73, 0.91)	0.72 (0.54, 0.91)			0.58 (0.51, 0.73)	0.58 (0.52, 0.79)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.076 (0.056, 0.096)	0.06 (0, 0.112)			0.048 (0, 0.097)	0.016 (0, 0.077)
TP53+	Carboplatin	count			24	24			24	24			24	24			24	24
		time			13 (9, 22)	13 (9, 22)			13 (9, 22)	13 (9, 22)			13 (9, 22)	13 (9, 22)			13 (9, 22)	13 (9, 22)
		n			10 (4, 17)	5 (1, 15)			4 (1, 7)	2 (1, 6)			3 (1, 5)	3 (0, 7)			3 (1, 8)	3 (1, 6)
		post_p			0.79 (0.55, 0.89)	0.72 (0.54, 0.8)			0.66 (0.56, 0.86)	0.64 (0.54, 0.8)			0.63 (0.53, 0.78)	0.68 (0.56, 0.86)			0.65 (0.54, 0.87)	0.69 (0.56, 0.85)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.071 (0.008, 0.101)	0.076 (0, 0.11)			0 (0, 0.041)	0.037 (0, 0.06)			0.058 (0, 0.11)	0.057 (0, 0.11)			0 (0, 0.076)	0 (0, 0.079)
	Hormone_therapies	count			5	5			5	5			5	5			5	5
		time			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)
		n			16 (14, 19)	4 (3, 7)			2 (1, 3)	0 (0, 2)			2 (0, 3)	1 (0, 3)			1 (0, 2)	0 (0, 1)
		post_p			0.86 (0.8, 0.94)	0.73 (0.66, 0.78)			0.58 (0.55, 0.61)	0.6 (0.55, 0.64)			0.6 (0.57, 0.76)	0.59 (0.54, 0.66)			0.54 (0.51, 0.57)	0.5 (0.5, 0.5)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.041 (0.022, 0.071)	0.048 (0, 0.063)			0 (0, 0)	0 (0, 0)			0 (0, 0.081)	0 (0, 0)			0 (0, 0)	0 (0, 0)
	Niraparib	count			27	27			27	27			27	27			27	27
		time			16 (10, 32)	16 (10, 32)			16 (10, 32)	16 (10, 32)			16 (10, 32)	16 (10, 32)			16 (10, 32)	16 (10, 32)
		n			16 (5, 34)	7 (3, 22)			4 (1, 7)	3 (0, 7)			3 (0, 11)	2 (1, 10)			4 (1, 11)	3 (2, 7)
		post_p			0.75 (0.57, 0.91)	0.71 (0.57, 0.9)			0.78 (0.61, 0.91)	0.69 (0.51, 0.87)			0.7 (0.52, 0.89)	0.63 (0.54, 0.88)			0.74 (0.52, 0.95)	0.72 (0.54, 0.89)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.086 (0.055, 0.107)	0.08 (0.028, 0.112)			0.03 (0, 0.085)	0.032 (0, 0.078)			0.056 (0, 0.104)	0.067 (0, 0.111)			0.027 (0, 0.07)	0.014 (0, 0.065)
	Taxel_therapies	count			2	2			2	2			2	2			2	2
		time			8 (7, 10)	8 (7, 10)			8 (7, 10)	8 (7, 10)			8 (7, 10)	8 (7, 10)			8 (7, 10)	8 (7, 10)
		n			6 (3, 10)	8 (5, 11)			1 (1, 1)	2 (0, 3)			3 (3, 3)	4 (3, 6)			0 (0, 1)	2 (1, 2)
		post_p			0.63 (0.56, 0.71)	0.74 (0.73, 0.74)			0.51 (0.5, 0.52)	0.55 (0.55, 0.55)			0.6 (0.56, 0.63)	0.76 (0.63, 0.89)			0.51 (0.51, 0.51)	0.56 (0.55, 0.58)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.126 (0.098, 0.155)	0.054 (0.011, 0.097)			0 (0, 0)	0 (0, 0)			0.078 (0.061, 0.096)	0 (0, 0)			0 (0, 0)	0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17
		time	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)	5 (4, 35)
		n	15 (11, 32)	2 (1, 6)	7 (4, 29)	2 (1, 9)	0 (0, 4)	0 (0, 7)	0 (0, 3)	0 (0, 2)	2 (0, 12)	2 (0, 5)	1 (0, 6)	2 (0, 6)	0 (0, 3)	0 (0, 4)	0 (0, 3)	0 (0, 2)
		post_p	0.27 (0.05, 0.45)	0.32 (0.23, 0.41)	0.33 (0.16, 0.39)	0.34 (0.26, 0.43)	0.33 (0.17, 0.5)	0.39 (0.29, 0.47)	0.18 (0.16, 0.37)	0.36 (0.31, 0.46)	0.36 (0.19, 0.48)	0.36 (0.25, 0.45)	0.33 (0.22, 0.48)	0.41 (0.37, 0.49)	0.39 (0.26, 0.47)	0.33 (0.27, 0.47)	0.4 (0.13, 0.46)	0.36 (0.33, 0.41)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.134 (0.078, 0.274)	0.18 (0.041, 0.346)	0.177 (0.117, 0.27)	0.228 (0.054, 0.6)	0.152 (0, 0.594)	0.108 (0.097, 0.839)	0.192 (0.06, 0.826)	0.974 (0.082, 5.57)	0.081 (0, 0.225)	0.158 (0, 0.272)	0.155 (0, 0.766)	0.19 (0.041, 0.258)	0.151 (0.076, 0.539)	0.108 (0, 0.205)	0.142 (0, 0.294)	0.33 (0.124, 27.05)
	Taxel_therapies	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)	22 (21, 24)
		n	27 (21, 33)	6 (4, 7)	8 (6, 9)	9 (4, 14)	3 (2, 4)	10 (5, 14)	3 (2, 4)	3 (2, 4)	6 (5, 6)	4 (4, 4)	2 (2, 3)	6 (5, 8)	4 (2, 5)	2 (1, 4)	5 (3, 7)	2 (1, 2)
		post_p	0.38 (0.35, 0.41)	0.31 (0.29, 0.33)	0.22 (0.22, 0.22)	0.3 (0.19, 0.41)	0.28 (0.27, 0.29)	0.24 (0.2, 0.29)	0.23 (0.2, 0.26)	0.38 (0.37, 0.4)	0.3 (0.15, 0.45)	0.45 (0.44, 0.45)	0.25 (0.17, 0.32)	0.39 (0.38, 0.41)	0.37 (0.3, 0.44)	0.18 (0.08, 0.28)	0.3 (0.22, 0.38)	0.19 (0.06, 0.33)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.13 (0.123, 0.138)	0.183 (0.156, 0.209)	0.226 (0.199, 0.253)	0.276 (0.167, 0.386)	0.263 (0.176, 0.349)	0.176 (0.143, 0.209)	0.223 (0.202, 0.245)	0.173 (0.123, 0.223)	0.223 (0.142, 0.305)	0.215 (0.207, 0.223)	0.285 (0.26, 0.309)	0.144 (0.127, 0.162)	0.069 (0.065, 0.074)	0.224 (0.174, 0.275)	0.802 (0.26, 1.345)	0.239 (0.236, 0.242)
DRD+	Hormone_therapies	count					78	78	78	78					78	78	78	78
		time					29 (22, 35)	29 (22, 35)	29 (22, 35)	29 (22, 35)					29 (22, 35)	29 (22, 35)	29 (22, 35)	29 (22, 35)
		n					4 (2, 10)	5 (1, 12)	3 (1, 8)	3 (1, 7)					3 (1, 7)	4 (1, 6)	4 (1, 7)	3 (1, 7)
		post_p					0.33 (0.12, 0.48)	0.31 (0.17, 0.45)	0.3 (0.16, 0.45)	0.32 (0.18, 0.45)					0.33 (0.18, 0.46)	0.31 (0.16, 0.47)	0.32 (0.15, 0.46)	0.35 (0.19, 0.44)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.158 (0.091, 0.488)	0.125 (0.087, 0.35)	0.172 (0.083, 0.679)	0.152 (0.089, 0.578)					0.147 (0.092, 0.599)	0.173 (0.101, 0.493)	0.15 (0.093, 0.422)	0.148 (0.093, 0.524)
	Taxel_therapies	count					92	92	92	92					92	92	92	92
		time					28 (21, 33)	28 (21, 33)	28 (21, 33)	28 (21, 33)					28 (21, 33)	28 (21, 33)	28 (21, 33)	28 (21, 33)
		n					5 (2, 11)	5 (2, 11)	3 (1, 7)	3 (1, 7)					3 (1, 6)	3 (1, 8)	3 (1, 7)	3 (1, 8)
		post_p					0.31 (0.17, 0.47)	0.32 (0.13, 0.48)	0.34 (0.2, 0.46)	0.33 (0.15, 0.47)					0.33 (0.17, 0.46)	0.34 (0.16, 0.45)	0.35 (0.19, 0.48)	0.3 (0.14, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.133 (0.089, 0.302)	0.143 (0.083, 0.37)	0.16 (0.085, 0.473)	0.144 (0.094, 0.51)					0.167 (0.09, 1.203)	0.139 (0.085, 0.447)	0.157 (0.083, 0.424)	0.153 (0.096, 0.646)
TEfus+	Hormone_therapies	count		59		59		59		59		59		59		59		59
		time		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)		23 (16, 32)
		n		4 (2, 9)		9 (4, 22)		4 (0, 9)		3 (0, 6)		3 (1, 9)		3 (1, 7)		2 (1, 5)		3 (1, 6)
		post_p		0.31 (0.12, 0.46)		0.34 (0.14, 0.47)		0.32 (0.16, 0.47)		0.37 (0.22, 0.46)		0.31 (0.18, 0.46)		0.34 (0.2, 0.46)		0.33 (0.21, 0.47)		0.35 (0.18, 0.48)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.186 (0.112, 0.525)		0.156 (0.111, 0.265)		0.13 (0.087, 0.658)		0.139 (0.076, 0.586)		0.188 (0.108, 0.682)		0.179 (0.107, 0.386)		0.162 (0.086, 0.545)		0.148 (0.077, 0.501)
	Taxel_therapies	count		68		68		68		68		68		68		68		68
		time		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)		23 (13, 32)
		n		5 (2, 11)		10 (6, 26)		3 (1, 7)		2 (1, 5)		5 (2, 10)		5 (2, 8)		2 (1, 7)		3 (0, 7)
		post_p		0.33 (0.13, 0.47)		0.29 (0.1, 0.47)		0.31 (0.16, 0.46)		0.32 (0.18, 0.48)		0.34 (0.19, 0.49)		0.35 (0.17, 0.48)		0.35 (0.16, 0.48)		0.39 (0.18, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.165 (0.112, 0.418)		0.142 (0.102, 0.298)		0.165 (0.082, 0.497)		0.163 (0.076, 0.363)		0.16 (0.095, 0.326)		0.167 (0.099, 0.443)		0.155 (0.079, 0.453)		0.146 (0.063, 0.393)
TP53- & AR-	Carboplatin	count	8	8			8	8
		time	17 (15, 24)	17 (15, 24)			17 (15, 24)	17 (15, 24)
		n	24 (16, 42)	3 (1, 12)			4 (1, 7)	4 (2, 12)
		post_p	0.28 (0.12, 0.44)	0.39 (0.17, 0.44)			0.29 (0.12, 0.43)	0.41 (0.32, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.14 (0.117, 0.189)	0.164 (0.107, 0.225)			0.212 (0.085, 0.539)	0.118 (0.055, 0.288)
	Hormone_therapies	count	220	220			220	220
		time	16 (8, 30)	16 (8, 30)			16 (8, 30)	16 (8, 30)
		n	24 (16, 56)	5 (2, 11)			3 (0, 8)	3 (0, 7)
		post_p	0.32 (0.11, 0.47)	0.38 (0.18, 0.49)			0.35 (0.17, 0.48)	0.36 (0.17, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.107, 0.173)	0.153 (0.089, 0.349)			0.139 (0.071, 0.538)	0.141 (0.069, 0.58)
	Niraparib	count	2	2			2	2
		time	17 (15, 19)	17 (15, 19)			17 (15, 19)	17 (15, 19)
		n	32 (18, 47)	2 (2, 3)			4 (3, 4)	5 (4, 6)
		post_p	0.34 (0.27, 0.41)	0.21 (0.16, 0.26)			0.3 (0.2, 0.39)	0.4 (0.39, 0.4)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.138 (0.121, 0.155)	0.573 (0.374, 0.773)			0.231 (0.144, 0.318)	0.118 (0.084, 0.153)
	Taxel_therapies	count	185	185			185	185
		time	21 (13, 32)	21 (13, 32)			21 (13, 32)	21 (13, 32)
		n	21 (10, 60)	6 (3, 13)			4 (1, 10)	4 (1, 9)
		post_p	0.34 (0.1, 0.47)	0.34 (0.15, 0.47)			0.32 (0.16, 0.47)	0.32 (0.15, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.106, 0.193)	0.155 (0.107, 0.345)			0.151 (0.083, 0.55)	0.142 (0.085, 0.428)
TP53+	Carboplatin	count			1	1			1	1			1	1			1	1
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			12 (12, 12)	5 (5, 5)			0 (0, 0)	2 (2, 2)			1 (1, 1)	1 (1, 1)			3 (3, 3)	2 (2, 2)
		post_p			0.36 (0.36, 0.36)	0.47 (0.47, 0.47)			NA (NA, NA)	0.38 (0.38, 0.38)			0.34 (0.34, 0.34)	0.34 (0.34, 0.34)			0.5 (0.5, 0.5)	0.36 (0.36, 0.36)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.17 (0.17, 0.17)	0.092 (0.092, 0.092)			NA (NA, NA)	0.165 (0.165, 0.165)			0.301 (0.301, 0.301)	0.565 (0.565, 0.565)			0.078 (0.078, 0.078)	0.592 (0.592, 0.592)
	Hormone_therapies	count			63	63			63	63			63	63			63	63
		time			23 (11, 33)	23 (11, 33)			23 (11, 33)	23 (11, 33)			23 (11, 33)	23 (11, 33)			23 (11, 33)	23 (11, 33)
		n			14 (8, 32)	8 (3, 22)			2 (1, 5)	2 (0, 7)			4 (1, 10)	3 (1, 7)			2 (0, 6)	2 (1, 6)
		post_p			0.3 (0.12, 0.47)	0.36 (0.12, 0.48)			0.35 (0.2, 0.47)	0.36 (0.21, 0.47)			0.36 (0.22, 0.47)	0.36 (0.22, 0.48)			0.37 (0.2, 0.45)	0.34 (0.17, 0.46)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.142 (0.111, 0.217)	0.139 (0.097, 0.316)			0.172 (0.066, 0.67)	0.153 (0.082, 0.595)			0.171 (0.097, 0.83)	0.176 (0.1, 0.546)			0.175 (0.075, 0.397)	0.181 (0.09, 0.828)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)
		n			6 (6, 6)	2 (2, 2)			4 (4, 4)	3 (3, 3)			3 (3, 3)	1 (1, 1)			3 (3, 3)	3 (3, 3)
		post_p			0.21 (0.21, 0.21)	0.28 (0.28, 0.28)			0.44 (0.44, 0.44)	0.33 (0.33, 0.33)			0.4 (0.4, 0.4)	0.21 (0.21, 0.21)			0.48 (0.48, 0.48)	0.46 (0.46, 0.46)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.195 (0.195, 0.195)	0.365 (0.365, 0.365)			0.077 (0.077, 0.077)	0.139 (0.139, 0.139)			0.277 (0.277, 0.277)	0.36 (0.36, 0.36)			0 (0, 0)	0.086 (0.086, 0.086)
	Taxel_therapies	count			63	63			63	63			63	63			63	63
		time			19 (10, 32)	19 (10, 32)			19 (10, 32)	19 (10, 32)			19 (10, 32)	19 (10, 32)			19 (10, 32)	19 (10, 32)
		n			9 (5, 25)	11 (5, 19)			2 (0, 4)	2 (0, 5)			4 (2, 9)	4 (1, 9)			2 (0, 6)	2 (0, 5)
		post_p			0.28 (0.16, 0.45)	0.37 (0.17, 0.48)			0.36 (0.22, 0.47)	0.33 (0.15, 0.48)			0.36 (0.17, 0.46)	0.35 (0.19, 0.45)			0.35 (0.22, 0.48)	0.39 (0.2, 0.5)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.146 (0.103, 0.254)	0.143 (0.103, 0.241)			0.162 (0.069, 0.646)	0.171 (0.078, 0.503)			0.162 (0.11, 0.422)	0.177 (0.102, 0.42)			0.159 (0.069, 0.531)	0.141 (0.062, 0.552)